Multisystem inflammatory syndrome in neonates associated with SARS-CoV-2 infection, a different entity?

Autor: Gámez-González LB; Immunology Department, Hospital Infantil de Especialidades de Chihuahua, Chihuahua, Mexico.; Hospital IMSS de Gineco Obstetricia No. 15, Chihuahua, Chihuahua, Mexico., Escárcega-Juárez Ana Silvia AS; Neonatology Department, Hospital IMSS de Gineco Obstetricia No. 15, Chihuahua, Chihuahua, Mexico., Aguilar-Soto DE; Cardiology Department, Hospital IMSS Morelos Chihuahua, Chihuahua, Mexico., Colmenero Rascón M; Cardiology Department, Hospital Angeles Chihuahua, Chihuahua, México., García Espinosa AC; Hospital IMSS de Gineco Obstetricia No. 15, Chihuahua, Chihuahua, Mexico.; Oncology Department, Hospital Infantil de Especialidades de Chihuahua, Chihuahua, Mexico., Yamazaki-Nakashimada MA; Immunology Department, Instituto Nacional de Pediatría, Mexico city, Mexico.
Jazyk: angličtina
Zdroj: Journal of neonatal-perinatal medicine [J Neonatal Perinatal Med] 2023; Vol. 16 (1), pp. 169-177.
DOI: 10.3233/NPM-220990
Abstrakt: Background: Multisystemic inflammatory syndrome in children (MIS-C) is a novel disease that is associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). MIS-C usually affects children older than 5 years of age and adolescents, with a median of 8-years and an interquartile range of 3 to 11 years. A multisystemic inflammatory disease has been described in neonates and named MIS-N (multisystemic inflammatory syndrome in Neonates). We report three cases of Mexican newborns with MIS-N presenting with multiorgan compromise and a positive anti-SARS-CoV-2 IgG who developed Kawasaki disease (KD)-like cardiac features and discuss the current dilemma regarding diagnosis and treatment in these patients.
Databáze: MEDLINE
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