Optimal Cerebral Perfusion Pressure and Brain Tissue Oxygen in Aneurysmal Subarachnoid Hemorrhage.
Autor: | Megjhani M; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.; Program in Hospital and Intensive Care Informatics of Department of Neurology (M.M., K.T., D.N., S.B.K., S.P.), Columbia University, NY., Weiss M; Department of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.).; Department of Neurosurgery, Kantonsspital Aarau, Switzerland (M.W., G.A.S.)., Ford J; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY., Terilli K; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.; Program in Hospital and Intensive Care Informatics of Department of Neurology (M.M., K.T., D.N., S.B.K., S.P.), Columbia University, NY., Kastenholz N; Department of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.)., Nametz D; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.; Program in Hospital and Intensive Care Informatics of Department of Neurology (M.M., K.T., D.N., S.B.K., S.P.), Columbia University, NY., Kwon SB; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.; Program in Hospital and Intensive Care Informatics of Department of Neurology (M.M., K.T., D.N., S.B.K., S.P.), Columbia University, NY., Velazquez A; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY., Agarwal S; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY., Roh DJ; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY., Conzen-Dilger C; Department of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.)., Albanna W; Department of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.)., Veldeman M; Department of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.)., Connolly ES Jr; Department of Neurosurgery (E.S.C.), Columbia University, NY., Claassen J; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY., Aries M; Department of Intensive Care, Maastricht University Medical Center, Maastricht University, the Netherlands (M.A.).; School for Mental Health and Neuroscience (MHeNS), Maastricht University Medical Center, the Netherlands (M.A.)., Schubert GA; Department of Neurosurgery, RWTH Aachen University, Germany (M.W., N.C.K., C.C.-D., W.A., M.V., G.A.S.).; Department of Neurosurgery, Kantonsspital Aarau, Switzerland (M.W., G.A.S.)., Park S; Department of Neurology (M.M., K.T., D.N., S.B.K., J.F., A.V., S.A., D.J.R., J.C., S.P.), Columbia University, NY.; Department of Biomedical Informatics (S.P.), Columbia University, NY.; Program in Hospital and Intensive Care Informatics of Department of Neurology (M.M., K.T., D.N., S.B.K., S.P.), Columbia University, NY. |
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Jazyk: | angličtina |
Zdroj: | Stroke [Stroke] 2023 Jan; Vol. 54 (1), pp. 189-197. Date of Electronic Publication: 2022 Oct 31. |
DOI: | 10.1161/STROKEAHA.122.040339 |
Abstrakt: | Background: Targeting a cerebral perfusion pressure optimal for cerebral autoregulation (CPPopt) has been gaining more attention to prevent secondary damage after acute neurological injury. Brain tissue oxygenation (PbtO Methods: We performed a retrospective analysis of a prospectively collected 2-center dataset of patients with aneurysmal subarachnoid hemorrhage with or without later diagnosis of delayed cerebral ischemia (DCI). CPPopt was calculated as the cerebral perfusion pressure (CPP) value corresponding to the lowest pressure reactivity index (moving correlation coefficient of mean arterial and intracranial pressure). The relationship of (hourly) deltaCPP (CPP-CPPopt) and PbtO Results: One hundred thirty-one patients were included with a median of 44.0 (interquartile range, 20.8-78.3) hourly CPPopt/PbtO2 datapoints. The regression plot revealed a nonlinear relationship between PbtO Conclusions: We found a nonlinear relationship between PbtO |
Databáze: | MEDLINE |
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