Physical Training Reduces Chronic Airway Inflammation and Mediators of Remodeling in Asthma.

Autor: Moraes-Ferreira R; Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Santos, SP, Brazil., Brandao-Rangel MAR; Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Santos, SP, Brazil., Gibson-Alves TG; Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Santos, SP, Brazil., Silva-Reis A; Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Santos, SP, Brazil., Souza-Palmeira VH; Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Santos, SP, Brazil., Aquino-Santos HC; Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Santos, SP, Brazil., Frison CR; Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Santos, SP, Brazil., Oliveira LVF; Unievangelica, Post-graduate Program in Human Movement and Rehabilitation and in Pharmaceutical Sciences, Anápolis, GO, Brazil., Albertini R; Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Santos, SP, Brazil., Vieira RP; Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Santos, SP, Brazil.; Unievangelica, Post-graduate Program in Human Movement and Rehabilitation and in Pharmaceutical Sciences, Anápolis, GO, Brazil.; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São José dos Campos, SP, Brazil.; Universidade Brasil, Post-graduate Program in Bioengineering, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Oct 20; Vol. 2022, pp. 5037553. Date of Electronic Publication: 2022 Oct 20 (Print Publication: 2022).
DOI: 10.1155/2022/5037553
Abstrakt: Several benefits of aerobic training for asthmatic patients have been demonstrated. However, its effects on systemic inflammation and on airway remodeling mediators and lung mechanics are unknown. This prospective study included 21 intermittent and mild asthma patients, and as primary outcomes, the evaluation of pro- and anti-inflammatory and pro- and antifibrotic mediators in exhaled breath condensate (EBC) and blood were performed, beyond the cell counting in blood and in induced sputum. Aerobic training was performed for 3 months, 3 times per week. Aerobic training increased the levels of anti-inflammatory cytokines and of antifibrotic mediators in the breath condensate: IL-1ra ( p = 0.0488), IL-10 ( p = 0.0048), relaxin-3 ( p = 0.0019), and klotho ( p < 0.0043), respectively. Similarly, in plasma, increased levels of IL-1ra ( p = 0.0147), IL-10 ( p < 0.0001), relaxin-3 ( p = 0.004), and klotho ( p = 0.0023) were found. On contrary, reduced levels of proinflammatory cytokines in the breath condensate, IL-1 β ( p = 0.0008), IL-4 ( p = 0.0481), IL-5 ( p < 0.0001), IL-6 ( p = 0.0032), IL-13 ( p = 0.0013), and TNF- α ( p = 0.0001) and profibrotic markers VEGF ( p = 0.0017) and TSLP ( p = 0.0056) were found. Similarly, in plasma, aerobic training significantly reduced the levels of proinflammatory cytokines IL-1 β ( p = 0.0008), IL-4 ( p = 0.0104), IL-5 ( p = 0.0001), IL-6 ( p = 0.006), IL-13 ( p = 0.0341), and TNF- α ( p = 0.0003) and of profibrotic markers VEGF ( p = 0.0009) and TSLP ( p < 0.0076). Fractional exhaled nitric oxide (FeNO) was reduced after the intervention ( p = 0.0313). Regarding inflammatory cells in sputum, there was a reduction in total cells ( p = 0.008), eosinophils ( p = 0.009), and macrophages ( p = 0.020), as well as of blood eosinophils ( p = 0.0203) and lymphocytes ( p = 0.0198). Aerobic training positively modulates chronic airway inflammation and remodeling mediators, beyond to improve systemic inflammation in intermittent and mild asthmatic patients.
Competing Interests: All authors have no conflicts of interest to declare.
(Copyright © 2022 Renilson Moraes-Ferreira et al.)
Databáze: MEDLINE
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