Resistance exercise and low-level laser therapy improves grip strength and morphological aspects in the ankle joint of Wistar rats with experimental arthritis.

Autor: Retameiro ACB; Center of Biological and Health Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil., Neves M; Center of Biological and Health Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil., Tavares ALF; Center of Biological and Health Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil., Boaro CT; Center of Biological and Health Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil., Rodriguez DFS; Center of Biological and Health Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil., Leal TSDS; Center of Biological and Health Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil., Costa RM; Center of Biological and Health Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil., Bertolini GRF; Center of Biological and Health Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil., Ribeiro LFC; Center of Biological and Health Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil.
Jazyk: angličtina
Zdroj: Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2023 Apr; Vol. 306 (4), pp. 918-932. Date of Electronic Publication: 2022 Nov 07.
DOI: 10.1002/ar.25112
Abstrakt: Rheumatoid arthritis (RA) is an inflammatory disease mainly affecting synovial joints. Photobiomodulation through low-level laser therapy (LLLT) and resistance exercise may improve the inflammatory process. Therefore, we analyzed the effects of resistance exercise, LLLT, and the combination of both treatments on hind paw grip strength and ankle joint histomorphometric aspects of Wistar rats subjected to experimental RA. A total of 64 male Wistar rats were divided into eight groups: control, control LLLT, control exercise, control LLLT and exercise, arthritis, arthritis LLLT, arthritis exercise, and arthritis LLLT and exercise groups. The experimental RA was induced by a complete Freund's adjuvant injection into the knee joint cavity. Climbing exercises and LLLT (660 nm; 5 J/cm 2 per point) were performed as the treatment. In addition, muscle strength was evaluated using the grip strength test, and morphometric evaluations were performed on the ankle joint. Generalized mixed models and multivariate analysis of variance tests were used for statistical analysis. Statistical significance was set at a p-value of .05. Arthritis LLLT, exercise, and LLLT and exercise had positive effects on grip strength between the groups (F[7.56] = 5.8, p < .004) and within the groups (F[4.3] = 9.9, p < .002) throughout the evaluations. Morphometry revealed degenerative lesions in the ankle joint as subintima with angiogenesis, inflammatory cells, flocculated articular cartilage, chondrocyte disorganization, and pannus in the arthritis group (p < .001). The treated groups exhibited morphological characteristics similar to those of the control group. LLLT and resistance exercise restored muscle strength and morphological aspects of the ankle joint in rats with experimentally induced RA.
(© 2022 American Association for Anatomy.)
Databáze: MEDLINE
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