Synthesis and characterization of gelatin/lignin hydrogels as quick release drug carriers for Ribavirin.

Autor: Chiani E; Department of Wood and Paper Science and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran. Electronic address: elahechiani@gmail.com., Beaucamp A; Stokes Laboratories, School of Engineering, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland; Health Research Institute and AMBER, University of Limerick, Limerick V94 T9PX, Ireland., Hamzeh Y; Department of Wood and Paper Science and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran; University Grenoble Alpes, CNRS, Grenoble INP Institute of Engineering Univ. Grenoble Alpes, LGP2, F-38000 Grenoble, France., Azadfallah M; Department of Wood and Paper Science and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran., Thanusha AV; Stokes Laboratories, School of Engineering, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland; Health Research Institute and AMBER, University of Limerick, Limerick V94 T9PX, Ireland., Collins MN; Stokes Laboratories, School of Engineering, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland; Health Research Institute and AMBER, University of Limerick, Limerick V94 T9PX, Ireland. Electronic address: maurice.collins@ul.ie.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Jan 01; Vol. 224, pp. 1196-1205. Date of Electronic Publication: 2022 Oct 26.
DOI: 10.1016/j.ijbiomac.2022.10.205
Abstrakt: In this study, hydrogels based on gelatin and lignin were fabricated as efficient drug carriers for Ribavirin. The obtained hydrogels were characterized by scanning electron microscopy (SEM), ATR-FTIR spectroscopy, differential scanning calorimetry (DSC), mechanical compression and rheometry. Results showed that the pore structure, viscoelastic behavior and swelling ability significantly influenced by varying lignin content and crosslinker ratio. By increasing the crosslinker N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) content, the pore size became smaller, while increasing the lignin content resulted in larger pores. In addition, all hydrogels show strong shear thinning behavior. Ribavirin was used as a drug model, and its release rate was enhanced by increasing lignin content in the binary hydrogel structure. A higher Ribavirin cumulative release was observed for gelatin/lignin with higher lignin content (3 %) hydrogel. These findings emphasize the chemical composition on the structure and the release behavior of lignin-containing hydrogels.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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