Synergic control in asymptomatic welders during multi-finger force exertion and load releasing while standing.

Autor: de Freitas PB; Interdisciplinary Graduate Program in Health Science, Universidade Cruzeiro do Sul, São Paulo, SP, Brazil., Freitas SMSF; Graduate Program in Physical Therapy, Universidade Cidade de São Paulo, São Paulo, SP, Brazil., Prado-Rico JM; Department of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA., Lewis MM; Department of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Department of Pharmacology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA., Du G; Department of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA., Yanosky JD; Department of Public Health Science, College of Medicine, The Pennsylvania State University, Hershey, PA, USA., Huang X; Department of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Department of Pharmacology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Radiology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Department of Neurosurgery, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA; Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA. Electronic address: Xuemei@psu.edu., Latash ML; Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA. Electronic address: mll11@psu.edu.
Jazyk: angličtina
Zdroj: Neurotoxicology [Neurotoxicology] 2022 Dec; Vol. 93, pp. 324-336. Date of Electronic Publication: 2022 Oct 26.
DOI: 10.1016/j.neuro.2022.10.012
Abstrakt: Motor synergies, i.e., neural mechanisms that organize multiple motor elements to ensure stability of actions, are affected by several neurological condition. Asymptomatic welders showed impaired synergy controlling the stability of multi-finger action compared to non-welders and this impairment was associated with microstructural damage in the globus pallidus. We further explored the effect of welding-related metal exposure on multi-finger synergy and extended our investigation to posture-stabilizing synergy during a standing task. Occupational, MRI, and performance-stabilizing synergies during multi-finger accurate force production and load releasing while standing were obtained from 29 welders and 19 age- and sex-matched controls. R2* and R1 relaxation rate values were used to estimate brain iron and manganese content, respectively, and diffusion tensor imaging was used to reflect brain microstructural integrity. Associations of brain MRI (caudate, putamen, globus pallidus, and red nucleus), and motor synergy were explored by group status. The results revealed that welders had higher R2* values in the caudate (p = 0.03), putamen (p = 0.01), and red nucleus (p = 0.08, trend) than controls. No group effect was revealed on multi-finger synergy index during steady-state phase of action (ΔV Z ss). Compared to controls, welders exhibited lower ΔV Z ss (-0.106 ± 0.084 vs. 0.160 ± 0.092, p = 0.04) and variance that did not affect the performance variable (V UCM , 0.022 ± 0.003 vs. 0.038 ± 0.007, p = 0.03) in the load releasing, postural task. The postural synergy index, ΔV Z ss, was associated negatively with higher R2* in the red nucleus in welders (r = -0.44, p = 0.03), but not in controls. These results suggest that the synergy index in the load releasing during a standing task may reflect welding-related neurotoxicity in workers with chronic metals exposure. This finding may have important clinical and occupational health implications.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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