Pulmonary Granuloma Is Not Always the Tuberculosis Hallmark: Pathology of Tuberculosis Stages in New World and Old World Monkeys Naturally Infected with the Mycobacterium tuberculosis Complex.

Autor: Pereira AHB; Pathological Anatomy Sector, Department of Epidemiology and Public Health, Veterinary Institute, Federal University Rural of Rio de Janeiro, Seropédica., Lopes CAA; Nonhuman Primate Breeding Service/Institute of Science and Technology in Biomodels, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro., Pissinatti TA; Nonhuman Primate Breeding Service/Institute of Science and Technology in Biomodels, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro., Pinto ACA; Nonhuman Primate Breeding Service/Institute of Science and Technology in Biomodels, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro., Oliveira DRA; National Laboratory for Tuberculosis and Other Mycobacterioses, Professor Hélio Fraga Reference Center, National School of Public Health, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro., Leal GM; Nonhuman Primate Breeding Service/Institute of Science and Technology in Biomodels, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro., Oliveira LCM; National Laboratory for Tuberculosis and Other Mycobacterioses, Professor Hélio Fraga Reference Center, National School of Public Health, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro., Redner P; National Laboratory for Tuberculosis and Other Mycobacterioses, Professor Hélio Fraga Reference Center, National School of Public Health, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro., Barbosa BEP; Residency Training Program in Wildlife Medicine and Conservation, Veterinary Institute, Federal University Rural of Rio de Janeiro, Seropédica., Moreira SB; Rio de Janeiro Primatology Center, Guapimirim., Pissinatti A; Rio de Janeiro Primatology Center, Guapimirim., Maruyama FH; Microbiology and Molecular Biology Laboratory, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil., Nakazato L; Microbiology and Molecular Biology Laboratory, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil., Dutra V; Microbiology and Molecular Biology Laboratory, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil., Ubiali DG; Pathological Anatomy Sector, Department of Epidemiology and Public Health, Veterinary Institute, Federal University Rural of Rio de Janeiro, Seropédica. Electronic address: danielubiali@ufrrj.br.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2022 Nov; Vol. 199, pp. 55-74. Date of Electronic Publication: 2022 Oct 26.
DOI: 10.1016/j.jcpa.2022.09.011
Abstrakt: We present the pathology of monkeys naturally infected with Mycobacterium tuberculosis complex from five different colonies in Rio de Janeiro, Brazil. On the basis of gross and histopathological findings, the lesions were classified into chronic-active, extrapulmonary, early-activation or latent-reactivation stages. Typical granulomatous pneumonia was seen in 46.6% of cases (six rhesus monkeys [Macaca mulatta] and one Uta Hick's bearded saki [Chiropotes utahickae]). The absence of pulmonary granulomas did not preclude a diagnosis of tuberculosis (TB): classical granulomatous pneumonia was observed in the chronic-active and latent-reactivation stages but not in the extrapulmonary and early-activation stages. The early-activation stage was characterized by interstitial pneumonia with a predominance of foamy macrophages and molecular and immunohistochemical evidence of M. tuberculosis complex infection. TB should be considered as a cause of interstitial pneumonia in New World Monkeys. We recommend the use of immunohistochemistry and molecular analysis for diagnosis of TB, even when typical macroscopic or histological changes are not observed.
Competing Interests: Conflict of Interest Statement The authors declared no potential conflicts of interest with respect to the research, authorship or publication of this article.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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