Engineered multicompartment vesicosomes for selective uptake by living cells.

Autor: Chernyshev VS; Center for Photonic Science and Engineering, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia; MIPT Life Sciences Center, Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia. Electronic address: v.chernyshev@skoltech.ru., Nozdriukhin D; Center for Photonic Science and Engineering, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia., Chuprov-Netochin R; MIPT Life Sciences Center, Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia., Tsydenzhapova E; MIPT Life Sciences Center, Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia., Novoselova M; Center for Photonic Science and Engineering, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia., Gorin D; Center for Photonic Science and Engineering, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia., Yashchenok A; Center for Photonic Science and Engineering, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia. Electronic address: a.yashchenok@skoltech.ru.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2022 Dec; Vol. 220, pp. 112953. Date of Electronic Publication: 2022 Oct 20.
DOI: 10.1016/j.colsurfb.2022.112953
Abstrakt: Small extracellular vesicles (sEVs) have attracted tremendous interest in recent years due to their exceptional properties for therapeutic and diagnostic applications. Although much research was focused on the quantity and content of sEVs, less efforts have been put into discovering the interaction between sEVs and cells. Here we engineered multicompartment particles, termed vesicosomes, by deposition of sEVs derived from MCF7, CHO cells and human plasma onto the surface of polyelectrolyte (PE)-coated silica (SiO 2 ) microparticles. Uptake of the PE-coated SiO 2 microparticles by parent cells was significantly enhanced by coating them with sEVs, compared to PE-coated SiO 2 microparticles independent of the terminated polyelectrolyte layer. This study highlights the emerging role of sEVs membrane receptors in the sEV-cells interaction and demonstrates the potential application of sEV-like multicompartment particles as therapeutic carriers.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Declaration of Competing Interest The authors declare that they have no relevant financial or non-financial competing interests to report.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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