Mitochondrial proteotoxicity: implications and ubiquitin-dependent quality control mechanisms.

Autor: Karbowski M; Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, 111 S. Penn St., Suite 104, Baltimore, MD, 21201, USA. mkarbowski@som.umaryland.edu.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. mkarbowski@som.umaryland.edu.; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA. mkarbowski@som.umaryland.edu., Oshima Y; Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, 111 S. Penn St., Suite 104, Baltimore, MD, 21201, USA.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA., Verhoeven N; Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, 111 S. Penn St., Suite 104, Baltimore, MD, 21201, USA.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.
Jazyk: angličtina
Zdroj: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Oct 29; Vol. 79 (11), pp. 574. Date of Electronic Publication: 2022 Oct 29.
DOI: 10.1007/s00018-022-04604-8
Abstrakt: Through their role in energy generation and regulation of several vital pathways, including apoptosis and inflammation, mitochondria are critical for the life of eukaryotic organisms. Mitochondrial dysfunction is a major problem implicated in the etiology of many pathologies, including neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), diabetes, cardiovascular diseases, and many others. Proteotoxic stress, here defined as a reduction in bioenergetic activity induced by the accumulation of aberrant proteins in the mitochondria, is likely to be implicated in disease-linked mitochondrial and cellular decline. Various quality control pathways, such as mitochondrial unfolded protein response (mtUPR), the ubiquitin (Ub)-dependent degradation of aberrant mitochondrial proteins, and mitochondria-specific autophagy (mitophagy), respond to proteotoxic stress and eliminate defective proteins or dysfunctional mitochondria. This work provides a concise review of mechanisms by which disease-linked aberrant proteins affect mitochondrial function and an overview of mitochondrial quality control pathways that counteract mitochondrial proteotoxicity. We focus on mitochondrial quality control mechanisms relying on the Ub-mediated protein degradation, such as mitochondria-specific autophagy and the mitochondrial arm of the Ub proteasome system (UPS). We highlight the importance of a widening perspective of how these pathways protect mitochondria from proteotoxic stress to better understand mitochondrial proteotoxicity in overlapping pathophysiological pathways. Implications of these mechanisms in disease development are also briefly summarized.
(© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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