| Autor: |
Silvère Gade I; Department of Organic Chemistry, Faculty of Science, The University of Yaounde I, Yaounde, Cameroon., Nyemb JN; Department of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, The University of Maroua, Kaele, Cameroon., Mahamat A; Department of Organic Chemistry, Faculty of Science, The University of Yaounde I, Yaounde, Cameroon., Atchade AT; Department of Organic Chemistry, Faculty of Science, The University of Yaounde I, Yaounde, Cameroon., Talla E; Department of Chemistry, Faculty of Science, University of Ngaoundere, Ngaoundéré, Cameroon., Laurent S; Laboratory of NMR and Molecular Imaging, Department of General, Organic Chemistry and Biomedical, University of MONS, Mons, Belgium., Henoumont C; Laboratory of NMR and Molecular Imaging, Department of General, Organic Chemistry and Biomedical, University of MONS, Mons, Belgium., Venditti A; Dipartimento di Chimica, 'Sapienza', Università di Roma, Rome, Italy. |
| Abstrakt: |
A phytochemical study was carried out on stem bark of Combretum fragrans F. Hoffm., a medicinal plant belonging to the Combretaceae family and used traditionally in the treatment of various ailments. Column chromatography separation on silica gel of the crude methanol extract from stem barks of C. fragrans led to the isolation of a new pentacyclic triterpene acid, with a 3,6-epoxide bridge and trivially named as fragransinic acid (1), along with four known compounds: betulin (2), betulinic acid (3), bellericagenin B (4) and a mixture of β -sitosterol (5) and stigmasterol (6). Structures were elucidated by extensive spectroscopic analyses including 1D and 2D NMR, mass spectrometry as well as by comparison with literature data. The above compounds were isolated for the first time from C. adenogonium . Implications for chemosystematics and traditional medicine were briefly discussed. |
