Sentinel Lymph Node Biopsy for Extremity and Truncal Soft Tissue Sarcomas: A Systematic Review of the Literature.

Autor: Keung EZ; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ekeung@mdanderson.org., Krause KJ; Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Maxwell J; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Morris CD; Department of Orthopedic Surgery, Johns Hopkins University, Baltimore, MD, USA., Crago AM; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Houdek MT; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA., Kane J; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Lewis V; Department of Orthopedic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Callegaro D; Department of Surgery, Sarcoma Service, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Miller B; Department of Orthopedic Surgery, University of Iowa, Iowa City, IA, USA., Lazar AJ; Department of Pathology and Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gladdy R; Department of Surgery, University of Toronto, Toronto, ON, Canada., Raut CP; Department of Surgery, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Fabbri N; Department of Orthopedic Surgery, NYU Langone Grossman School of Medicine, New York, NY, USA., Al-Refaie W; Department of Surgery, Georgetown University Medical Center, Washington, DC, USA., Fairweather M; Department of Surgery, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Wong SL; Department of Surgery, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Roland CL; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jazyk: angličtina
Zdroj: Annals of surgical oncology [Ann Surg Oncol] 2023 Feb; Vol. 30 (2), pp. 958-967. Date of Electronic Publication: 2022 Oct 28.
DOI: 10.1245/s10434-022-12688-6
Abstrakt: Background: Regional lymph node metastasis (RLNM) occurs infrequently in patients with soft tissue sarcoma (STS), although certain STS subtypes have a higher propensity for RLNM. The identification of RLNM has significant implications for staging and prognosis; however, the precise impact of node-positive disease on patient survival remains a topic of controversy. Although the benefits of sentinel lymph node biopsy (SLNB) are well documented in patients with melanoma and breast cancer, whether this procedure offers a benefit in STS is controversial.
Methods: A systematic literature search was performed and articles reviewed to determine if SLNB in patients with extremity/truncal STS impacts disease-free or overall survival.
Results: Six studies were included. Rates of sentinel lymph node positivity were heterogeneous (range 4.3-50%). The impact of SLNB on patient outcomes remains unclear. The overall quality of available evidence was low, as assessed by the Grading of Recommendations, Assessment, Development, and Evaluation system.
Conclusions: The literature addressing the impact of nodal basin evaluation on the staging and management of patients with extremity/truncal STS is confounded by heterogeneous patient cohorts and clinical practices. Multicenter prospective studies are warranted to determine the true incidence of RLNM and whether SLNB could benefit patients with clinically occult RLNM at diagnosis.
(© 2022. Society of Surgical Oncology.)
Databáze: MEDLINE
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