Phytochemical profile and anthelmintic effects of Laurus nobilis essential oil against the ovine nematode Haemonchus contortus and the murine helminth model Heligmosomoides polygyrus.

Autor: Sebai E; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020 Sidi Thabet, Tunisia; Faculty of Sciences of Tunis, University of Tunis El Manar, 2092 Manar II Tunis, Tunisia. Electronic address: essiasebai@yahoo.fr., Abidi A; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020 Sidi Thabet, Tunisia; Faculty of Sciences of Tunis, University of Tunis El Manar, 2092 Manar II Tunis, Tunisia., Benyedem H; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020 Sidi Thabet, Tunisia., Dhibi M; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020 Sidi Thabet, Tunisia., Hammemi I; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020 Sidi Thabet, Tunisia., Akkari H; Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi Thabet, 2020 Sidi Thabet, Tunisia.
Jazyk: angličtina
Zdroj: Veterinary parasitology [Vet Parasitol] 2022 Dec; Vol. 312, pp. 109835. Date of Electronic Publication: 2022 Oct 21.
DOI: 10.1016/j.vetpar.2022.109835
Abstrakt: Small ruminant production in tropical and temperate countries faced substantial anthelmintic resistance due to the intensive use of commercial anthelmintic drugs. Therefore, alternative treatments including natural bioactive compounds with anthelmintic potential have been investigated looking for its successfully use in the parasite control. In the present study, we describe the chemical profile of Laurus nobilis essential oil (EO), the in vitro anthelmintic activity of L. nobilis EO against Haemonchus contortus and its in vivo anthelmintic effect against the murine helminth parasite model Heligmosomoides polygyrus. Chromatographic profile of L. nobilis (EO) extracted from the leaves of L. nobilis have shown the presence of monterpens 1,8-cineol (Eucalyptol) (29.47%), D-Limonène (18.51%) and Linalool (10.84%) in high fractions. The in vitro anthelmintic potential was expressed by an ovicidal effect against H. contortus egg hatching with inhibition value of 1.72 mg/mL and 87.5% of immobility of adult worms after 8 h of exposure to 4 mg/mL of L. nobilis EO. Regarding, the in vivo anthelmintic potential, L. nobilis (EO) at 2400 mg/kg bw completely eliminated the egg output of H. polygyrus after 7 days of oral treatment, together with a 79.2% of reduction in total worm counts. Based on the obtained results, L. nobilis EO showed promising in vitro and in vivo anthelmintic capacities against gastrointestinal parasites.
Competing Interests: Conflict of interest The authors declare no conflicts of interest in relation to this work.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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