Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals.

Autor:	Hollitt GL; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia., Siggs OM; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia.; Garvan Institute of Medical Research Institute, Darlinghurst, Sydney, Australia., Ridge B; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia., Keane MC; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia., Mackey DA; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Lions Eye Institute, Centre for Ophthalmology and Vision Sciences, University of Western Australia, Perth, Western Australia, Australia., MacGregor S; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Hewitt AW; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Craig JE; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia., Souzeau E; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia.
Jazyk:	angličtina
Zdroj:	Translational vision science & technology [Transl Vis Sci Technol] 2022 Oct 03; Vol. 11 (10), pp. 38.
DOI:	10.1167/tvst.11.10.38
Abstrakt:	Purpose: Integrating polygenic risk scores (PRS) into healthcare has the potential to stratify an individual's risk of glaucoma across a broad population. Glaucoma is the most common cause of irreversible blindness worldwide, therefore effective screening for glaucoma endorsed by the population is highly important. This study assessed the attitude of unaffected individuals toward PRS testing for glaucoma, and sought to identify factors associated with interest in testing. Methods: We surveyed 418 unaffected individuals including 193 with a first-degree relative with glaucoma, 117 who had a recent eye examination, and 108 general members of the community. Results: Overall, 71.3% of the individuals indicated an interest in taking a polygenic risk test for glaucoma. Interest was more likely in those who believed glaucoma to be a severe medical condition (odds ratio [OR] = 14.58, 95% confidence interval [CI] = 1.15-185.50, P = 0.039), those concerned about developing glaucoma (OR = 4.37, 95% CI = 2.32-8.25, P < 0.001), those with an intention to take appropriate measures regarding eye health (OR = 2.39, 95% CI = 1.16-4.95, P = 0.019), and those preferring to know if considered to be at-risk or not (OR = 4.52, 95% CI = 2.32-8.83, P < 0.001). Conclusions: Our results show strong interest in genetic risk assessment for glaucoma among unaffected individuals in Australia. Translational Relevance: These findings represent a valuable assessment of interest in glaucoma polygenic risk testing among potential target populations, which will be integral to the implementation and uptake of novel PRS-based tests into clinical practice.
Databáze:	MEDLINE
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