Intermittent fasting and exercise therapy abates STZ-induced diabetotoxicity in rats through modulation of adipocytokines hormone, oxidative glucose metabolic, and glycolytic pathway.

Autor: Chijiokwu EA; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria., Nwangwa EK; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria., Oyovwi MO; Department of Human Physiology, Achievers University, Owo, Ondo State, Nigeria., Naiho AO; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria., Emojevwe V; Department of Physiology, University of Medical Sciences, Ondo, Ondo State, Nigeria., Ohwin EP; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria., Ehiwarior PA; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria., Ojugbeli ET; Department of Medical Biochemistry, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria., Nwabuoku US; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria., Oghenetega OB; Department of Physiology, Faculty of Basic Medical Science, Babcock University, Ilisan-Romo, Ogun State, Nigeria., Ogheneyoma OO; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2022 Oct; Vol. 10 (20), pp. e15279.
DOI: 10.14814/phy2.15279
Abstrakt: Diabetes is a global, costly, and growing public health issue. Intermittent fasting (IF) and exercise therapy have been shown to improve insulin sensitivity (IS) in large studies, although the underlying processes are still unknown. The goal of this study, which included both nondiabetic and diabetic rats, was to look at the mechanisms of intermittent fasting and exercise in the management of diabetotoxicity. The effects of starvation and honey on the oral glucose tolerance test, insulin tolerance test, adipocytokines, oxidative glucose metabolic enzymes, glycolytic enzymes, food intake, and body weight in rats with streptozotocin-induced diabetes were also investigated. In the nondiabetic phase, rats were administered an oral regimen of distilled water (0.5 ml/rat), honey (1 g/kg body weight), and interventions with IF, and starvation for 4 weeks while in the diabetic phase, after STZ or citrate buffer injections, interventions with IF, exercise, starvation, and honey treatment began for 4 weeks. At all OGTT and ITT points, there was a substantial rise in glucose in the STZ group. Adipocytokines hormone, oxidative glucose metabolic enzymes, glycolytic enzymes, and body weight were all affected by STZ when compared to starvation and honey, however, IF and exercise significantly reduced these alterations. In diabetic rats, intermittent fasting and exercise enhanced serum adipocytokines levels. These findings imply that adipokines modulate glycolytic/nonmitochondrial enzymes and glucose metabolic/mitochondrial dehydrogenase to mediate the antidiabetic effects of intermittent fasting and exercise.
(© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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