TNFRSF13B/TACI Mutations in Patients with Chronic Rhinosinusitis with Nasal Polyps.

Autor:	Tsiouma GK; Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, 82956University of Thessaly, Larissa, Thessaly, Greece.; ENT Department, 69212General Hospital of Volos, Volos, Greece., Skoulakis CE; ENT Department, University Hospital of Larissa, Larissa, Thessaly, Greece.; Faculty of Medicine, School of Health Sciences, 82956University of Thessaly, Larissa, Thessaly, Greece., Lachanas VA; ENT Department, University Hospital of Larissa, Larissa, Thessaly, Greece., Sevdali EG; Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, 82956University of Thessaly, Larissa, Thessaly, Greece., Tsinti GN; Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, 82956University of Thessaly, Larissa, Thessaly, Greece., Florou ZA; Department of Microbiology, Faculty of Medicine, School of Health Sciences, 82956University of Thessaly, Larissa, Thessaly, Greece., Petinaki EA; Department of Microbiology, Faculty of Medicine, School of Health Sciences, 82956University of Thessaly, Larissa, Thessaly, Greece., Speletas MG; Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, 82956University of Thessaly, Larissa, Thessaly, Greece.
Jazyk:	angličtina
Zdroj:	American journal of rhinology & allergy [Am J Rhinol Allergy] 2023 Jan; Vol. 37 (1), pp. 74-77. Date of Electronic Publication: 2022 Oct 27.
DOI:	10.1177/19458924221134731
Abstrakt:	Background: The pathogenesis of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) remains still inconclusive. Recent studies identified an increased expression of BAFF (a B cell-activating factor) and its receptor TACI (Transmembrane Activator and cAML Interactor) in nasal polyp samples, while TNFRSF13B/TACI mutations have been found in patients with benign lymphoproliferative disorders and primary antibody deficiencies. Objective: The aim of our study was to evaluate the possible contribution of TNFRSF13B/TACI mutations in CRSwNP pathogenesis. Methods: Forty-four (44) patients with CRSwNP (male/female: 33/11, mean age: 52.5 years, range: 16-83) were analyzed for TNFRSF13B/TACI mutations by PCR-sequencing. Results: No pathogenic TNFRSF13B/TACI mutations were identified in our cohort study of CRSwNP patients. We detected two common missense mutations (p.P251L and p.V220A), along with other common silent mutations and intronic polymorphisms in an identical prevalence to healthy control population. Conclusion: TNFRSF13B/TACI mutations might not play a role in the pathogenesis of CRSwNP.
Databáze:	MEDLINE
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