Early remission in multiple sclerosis is linked to altered coherence of the Cerebellar Network.

Autor: Tahedl M; Department of Psychiatry and Psychotherapy, University of Regensburg, 93053, Regensburg, Germany.; Institute for Psychology, University of Regensburg, 93053, Regensburg, Germany., Levine SM; Department of Psychology, LMU Munich, 80802, Munich, Germany.; NeuroImaging Core Unit Munich (NICUM), University Hospital LMU, 80336, Munich, Germany., Weissert R; Department of Neurology, University of Regensburg, 93053, Regensburg, Germany., Kohl Z; Department of Neurology, University of Regensburg, 93053, Regensburg, Germany., Lee DH; Department of Neurology, University of Regensburg, 93053, Regensburg, Germany., Linker RA; Department of Neurology, University of Regensburg, 93053, Regensburg, Germany., Schwarzbach JV; Department of Psychiatry and Psychotherapy, University of Regensburg, 93053, Regensburg, Germany. jens.schwarzbach@ukr.de.
Jazyk: angličtina
Zdroj: Journal of translational medicine [J Transl Med] 2022 Oct 27; Vol. 20 (1), pp. 488. Date of Electronic Publication: 2022 Oct 27.
DOI: 10.1186/s12967-022-03576-4
Abstrakt: Background: The development of permanent disability in multiple sclerosis (MS) is highly variable among patients, and the exact mechanisms that contribute to this disability remain unknown.
Methods: Following the idea that the brain has intrinsic network organization, we investigated changes of functional networks in MS patients to identify possible links between network reorganization and remission from clinical episodes in MS. Eighteen relapsing-remitting MS patients (RRMS) in their first clinical manifestation underwent resting-state functional MRI and again during remission. We used ten template networks, identified from independent component analysis, to compare changes in network coherence for each patient compared to those of 44 healthy controls from the Human Connectome Project test-retest dataset (two-sample t-test of pre-post differences). Combining a binomial test with Monte Carlo procedures, we tested four models of how functional coherence might change between the first clinical episode and remission: a network can change its coherence (a) with itself ("one-with-self"), (b) with another network ("one-with-other"), or (c) with a set of other networks ("one-with-many"), or (d) multiple networks can change their coherence with respect to one common network ("many-with-one").
Results: We found evidence supporting two of these hypotheses: coherence decreased between the Executive Control Network and several other networks ("one-with-many" hypothesis), and a set of networks altered their coherence with the Cerebellar Network ("many-with-one" hypothesis).
Conclusion: Given the unexpected commonality of the Cerebellar Network's altered coherence with other networks (a finding present in more than 70% of the patients, despite their clinical heterogeneity), we conclude that remission in MS may result from learning processes mediated by the Cerebellar Network.
(© 2022. The Author(s).)
Databáze: MEDLINE
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