Physical activity volume, intensity, and incident cardiovascular disease.

Autor:	Dempsey PC; Diabetes Research Centre, College of Life Sciences, University of Leicester, Gwendolen Road, Leicester, LE54PW, UK.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Baker Heart and Diabetes Institute, Melbourne, Australia.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Rowlands AV; Diabetes Research Centre, College of Life Sciences, University of Leicester, Gwendolen Road, Leicester, LE54PW, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Strain T; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Zaccardi F; Diabetes Research Centre, College of Life Sciences, University of Leicester, Gwendolen Road, Leicester, LE54PW, UK.; Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK., Dawkins N; Diabetes Research Centre, College of Life Sciences, University of Leicester, Gwendolen Road, Leicester, LE54PW, UK.; School of Social and Health Sciences, Leeds Trinity University, Leeds, UK., Razieh C; Diabetes Research Centre, College of Life Sciences, University of Leicester, Gwendolen Road, Leicester, LE54PW, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.; Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK., Davies MJ; Diabetes Research Centre, College of Life Sciences, University of Leicester, Gwendolen Road, Leicester, LE54PW, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Khunti KK; Diabetes Research Centre, College of Life Sciences, University of Leicester, Gwendolen Road, Leicester, LE54PW, UK.; Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK., Edwardson CL; Diabetes Research Centre, College of Life Sciences, University of Leicester, Gwendolen Road, Leicester, LE54PW, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Wijndaele K; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Brage S; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Yates T; Diabetes Research Centre, College of Life Sciences, University of Leicester, Gwendolen Road, Leicester, LE54PW, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.
Jazyk:	angličtina
Zdroj:	European heart journal [Eur Heart J] 2022 Dec 07; Vol. 43 (46), pp. 4789-4800.
DOI:	10.1093/eurheartj/ehac613
Abstrakt:	Aims: The interplay between physical activity (PA) volume and intensity is poorly understood in relation to cardiovascular disease (CVD) risk. This study aimed to investigate the role of PA intensity, over and above volume, in relation to incident CVD. Methods and Results: Data were from 88 412 UK Biobank middle-aged adults (58% women) without prevalent CVD who wore accelerometers on their dominant wrist for 7 days, from which we estimated total PA energy expenditure (PAEE) using population-specific validation. Cox proportional hazards regressions modelled associations between PAEE (kJ/kg/day) and PA intensity (%MVPA; the fraction of PAEE accumulated from moderate-to-vigorous-intensity PA) with incident CVD (ischaemic heart disease or cerebrovascular disease), adjusted for potential confounders. There were 4068 CVD events during 584 568 person-years of follow-up (median 6.8 years). Higher PAEE and higher %MVPA (adjusted for PAEE) were associated with lower rates of incident CVD. In interaction analyses, CVD rates were 14% (95% confidence interval: 5-23%) lower when MVPA accounted for 20% rather than 10% of 15 kJ/kg/d PAEE; equivalent to converting a 14 min stroll into a brisk 7 min walk. CVD rates did not differ significantly between values of PAEE when the %MVPA was fixed at 10%. However, the lowest CVD rates were observed for combinations of both higher PAEE and %MVPA. Conclusion: Reductions in CVD risk may be achievable through higher PA volume and intensity, with the role of moderately intense PA appearing particularly important. This supports multiple approaches or strategies to PA participation, some of which may be more practical or appealing to different individuals. Competing Interests: Conflict of interest: None declared. (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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