| Autor: |
Dong S; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China., Zhou Y; Yulin Food and Drug Inspection and Testing Center, Yulin, China., Wang JC; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China., Zhuo YL; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China., Sun YH; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China., Wang JG; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China., Zhang GG; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China. |
| Abstrakt: |
A new flavonoid (bunge A) ( 1 ), a new sesquiterpene (bunge B) ( 8 ), a new furan derivative (bunge C) ( 12 ) and a new alkenoic acid (bunge D) ( 14 ), together with ten known ones [four flavonoids ( 2 , 3 , 4 , 5 ), two phenylpropanoids ( 6 , 7 ), three sesquiterpenes ( 9 , 10 , 11 ) and one lactone ( 13 )] were isolated from the fruits of Prunus humilis Bunge [ Cerasus humilis (Bunge) Sokolov]. Their structures were elucidated based on extensive spectroscopic analysis (including HR-ESI-MS and NMR) and comparison with previously published data. All compounds were evaluated for cytotoxic activity against three human tumour cell lines. Compound 3 and 4 showed weak antiproliferative activities against hepatocarcinoma cell HepG-2 at the concentration of 100 μ M, which the inhibition rates were 55.34 ± 0.29 and 45.52 ± 0.37, respectively. And other compounds had almost no cytotoxic activity against the three tumour cell lines in vitro . |
