Peptide Tyrosine-Tyrosine Triggers GLP-2-Mediated Intestinal Hypertrophy After Roux-en-Y Gastric Bypass.

Autor: Pérez-Arana GM; Department of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003, Plaza Fragela s/n., Cadiz, Spain. gonzalo.perez@uca.es.; Institute for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, 11009, Cadiz, Spain. gonzalo.perez@uca.es., Díaz-Gómez A; San Carlos Hospital, Andalusian Health System, 11100, Andalusia, Spain., Camacho-Ramírez A; Institute for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, 11009, Cadiz, Spain.; Surgery Unit, Puerta del Mar University Hospital, University of Cadiz, 11009, Cadiz, Spain., Ribelles-García A; Department of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003, Plaza Fragela s/n., Cadiz, Spain., Almorza-Gomar D; Institute for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, 11009, Cadiz, Spain.; Operative Statistic and Research Department, University of Cádiz, 11003, Cadiz, Spain., Gracia-Romero M; Department of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003, Plaza Fragela s/n., Cadiz, Spain.; Intensive Care Unit, Jerez University Hospital, Andalusian Health System, 11407, Andalusia, Spain., Prada-Oliveira JA; Department of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003, Plaza Fragela s/n., Cadiz, Spain. arturo.prada@uca.es.; Institute for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, 11009, Cadiz, Spain. arturo.prada@uca.es.
Jazyk: angličtina
Zdroj: Obesity surgery [Obes Surg] 2022 Dec; Vol. 32 (12), pp. 4023-4032. Date of Electronic Publication: 2022 Oct 27.
DOI: 10.1007/s11695-022-06328-x
Abstrakt: PURPOSE : Intestinal remodeling and adaptation of the alimentary limb after Roux-en-Y gastric bypass (RYGB) play an important role in the pathophysiological events that lead to type 2 diabetes mellitus (T2DM) improvement. Intestinal absorptive loop hypertrophy and growth following surgery have been related to GLP-2 secretion by ileal L-cells. The secretion of peptide tyrosine-tyrosine (PYY) enterohormone after a meal has been proposed as a trigger for ileal secretion of GLP-1. Our aim is to determine the role of PYY as a GLP-2 secretion modulator as an adaptation result in the alimentary limb after RYGB.
Method: We used a non-obese euglycemic rodent model. Circulating glucose, insulin, PYY, and GLP-2 were measured in the experimental and control groups. We used four groups: fasting control, Sham-operated, RYGB-operated (RYGB), and RYGB-operated and treated with BIIE0246 (RYGB + BII). BIIE0246 is a NPY2 receptor antagonist in L-cells. Intestinal glucose transporters and GLP-1 and PYY gut expression and hypertrophy were analyzed after 12 weeks of surgery.
Results: RYGB increased PYY3-36 plasma levels in rats with or without BII treatment. A high-insulin response was observed in the RYGB group but not in the control or RYGB + BII groups. BIIE0246 treatment limited plasma GLP-2 levels. In the alimentary intestinal limb, hypertrophy and SGLT1 and GLUT1 expression appeared to be reduced after RYGB compared to controls.
Conclusion: The postprandial ileal PYY secretion is enhanced after RYGB. This increase mediates GLP-2 release through its binding to the Y2 receptor on L-cells. This mechanism plays a role in alimentary limb hypertrophy after surgery.
(© 2022. The Author(s).)
Databáze: MEDLINE
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