Clinical and Laboratory Findings by Serum Vitamin D Levels in Children with COVID-19.

Autor: Ozden A; Department of Pediatric Endocrinology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey., Doneray H; Department of Pediatric Endocrinology, Atatürk University Faculty of Medicine, Erzurum, Turkey; Clinical Research Development and Design Application and Research Center, Atatürk University, Erzurum, Turkey., Hafize Erdeniz EH; Department of Pediatric Infectious Diseases, Erzurum Regional Training and Research Hospital, Erzurum, Turkey., Altinkaynak K; Department of Biochemistry, Erzurum Regional Training and Research Hospital, Erzurum, Turkey., Igan H; Department of Medical Microbiology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
Jazyk: angličtina
Zdroj: The Eurasian journal of medicine [Eurasian J Med] 2022 Oct; Vol. 54 (3), pp. 285-291.
DOI: 10.5152/eurasianjmed.2022.22213
Abstrakt: Objective: The studies on children with COVID-19 are very limited. The aim of this study is to reveal the effect of serum 25-hydroxy vitamin D level on clinical and laboratory parameters.
Materials and Methods: The study included 74 children (35 boys and 39 girls) diagnosed with COVID-19. The retrospective data were obtained from the file records of the patients. Seventy-four patients were divided into 3 groups (group 1, deficient; group 2, insufficient; and group 3, sufficient) according to their serum 25-hydroxy vitamin D levels.
Results: The mean age of all patients was 113.25 ± 64.55 months. The mean leucocyte count was substantially higher in group 3 compared to groups 1 and 2 (P = .05 and P = .002, respectively). The mean lymphocyte and platelet count in group 3 was remarkably higher than both groups 1 and 2 (P = .001 and P = .002; and P = .04 and P = .01, respectively). The mean serum parathyroid hormone concentration in group 1 was markedly higher than both groups 2 and 3 (P=.003 and P = .002, respectively) while the mean serum 25-hydroxy vitamin D level in group 1 was remarkably lower than both groups 2 and 3 (P=.001 and P=.001, respectively). Serum 25-hydroxy vitamin D concentrations were positively correlated with leucocyte, lymphocyte, and platelet counts (r=0.221, P=.05; r=0.396, P=.001; and r=0.249, P=.03, respectively) while there was a negative correlation with parathyroid hormone concentrations (r=-0,436, P=.001).
Conclusion: This study suggests that COVID-19 has a benign course in children and that serum 25-hydroxy vitamin D concentration may have a role in the lymphocyte count.
Databáze: MEDLINE
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