Drug use and severe outcomes among adults hospitalized with influenza, 2016-2019.

Autor: Parisi CE; Department of Epidemiology, University of Florida, Gainesville, Florida, USA.; Emerging Infections Program, Yale University School of Public Health, New Haven, Connecticut, USA., Yousey-Hindes K; Emerging Infections Program, Yale University School of Public Health, New Haven, Connecticut, USA., Holstein R; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., O'Halloran A; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Kirley PD; California Emerging Infections Program, Oakland, California, USA., Alden NB; Colorado Department of Public Health and Environment, Denver, Colorado, USA., Anderson EJ; Emory University School of Medicine, Atlanta, Georgia, USA.; Georgia Emerging Infections Program, Atlanta, Georgia, USA.; Atlanta VA Medical Center, Decatur, Georgia, USA., Kim S; Michigan Department of Health and Human Services, Lansing, Michigan, USA., McMahon M; Minnesota Department of Health, St. Paul, Minnesota, USA., Khanlian SA; New Mexico Department of Health, Santa Fe, New Mexico, USA., Spina N; New York State Department of Health, Albany, New York, USA., Gaitan MA; Center for Community Health and Prevention, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA., Shiltz E; Ohio Department of Health, Columbus, Ohio, USA., Thomas A; Oregon Health Authority, Portland, Oregon, USA., Schaffner W; Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Talbot K; Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Crossland MT; Salt Lake County Health Department, Salt Lake City, Utah, USA., Cook RL; Department of Epidemiology, University of Florida, Gainesville, Florida, USA., Garg S; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Meek J; Emerging Infections Program, Yale University School of Public Health, New Haven, Connecticut, USA., Hadler J; Emerging Infections Program, Yale University School of Public Health, New Haven, Connecticut, USA.
Jazyk: angličtina
Zdroj: Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2023 Jan; Vol. 17 (1), pp. e13052. Date of Electronic Publication: 2022 Oct 27.
DOI: 10.1111/irv.13052
Abstrakt: Background: Influenza is a persistent public health problem associated with severe morbidity and mortality. Drug use is related to myriad health complications, but the relationship between drug use and severe influenza outcomes is not well understood. The study objective was to evaluate the relationship between drug use and severe influenza-associated outcomes.
Methods: Data were collected by the Influenza Hospitalization Surveillance Network (FluSurv-NET) from the 2016-2017 through 2018-2019 influenza seasons. Among persons hospitalized with influenza, descriptive statistics and logistic regression models were used to analyze differences in demographic characteristics, risk and behavioral factors, and severe outcomes (intensive care unit [ICU] admission, mechanical ventilation, or death) between people who use drugs (PWUD), defined as having documented drug use within the past year, and non-PWUD.
Results: Among 48,430 eligible hospitalized influenza cases, 2019 were PWUD and 46,411 were non-PWUD. PWUD were younger than non-PWUD and more likely to be male, non-Hispanic Black or Hispanic/Latino, smoke tobacco, abuse alcohol, and have chronic conditions including asthma, chronic liver disease, chronic lung disease, or immunosuppressive conditions. PWUD had greater odds of ICU admission and mechanical ventilation, but not death compared with non-PWUD; however, these findings were not statistically significant after adjustment. Opioid use specifically was associated with increased risk of ICU admission and mechanical ventilation.
Conclusion: These results support targeted initiatives to prevent influenza in this population, including influenza vaccination, which remains one of the most important tools to prevent influenza infection and associated severe outcomes.
(© 2022 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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