Graphene Oxide Nanoscale Platform Enhances the Anti-Cancer Properties of Bortezomib in Glioblastoma Models.

Autor: Sharp PS; Nanomedicine Lab, Faculty of Biology, Medicine & Health, National Graphene Institute, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK., Stylianou M; Nanomedicine Lab, Faculty of Biology, Medicine & Health, National Graphene Institute, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK., Arellano LM; Catalan Institute of Nanoscience and Nanotechnology (ICN2), Campus UAB, Bellaterra, Barcelona, 08193, Spain., Neves JC; Catalan Institute of Nanoscience and Nanotechnology (ICN2), Campus UAB, Bellaterra, Barcelona, 08193, Spain., Gravagnuolo AM; Nanomedicine Lab, Faculty of Biology, Medicine & Health, National Graphene Institute, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK., Dodd A; Nanomedicine Lab, Faculty of Biology, Medicine & Health, National Graphene Institute, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK., Barr K; Nanomedicine Lab, Faculty of Biology, Medicine & Health, National Graphene Institute, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK., Lozano N; Catalan Institute of Nanoscience and Nanotechnology (ICN2), Campus UAB, Bellaterra, Barcelona, 08193, Spain., Kisby T; Nanomedicine Lab, Faculty of Biology, Medicine & Health, National Graphene Institute, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK., Kostarelos K; Nanomedicine Lab, Faculty of Biology, Medicine & Health, National Graphene Institute, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK.; Catalan Institute of Nanoscience and Nanotechnology (ICN2), Campus UAB, Bellaterra, Barcelona, 08193, Spain.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2023 Jan; Vol. 12 (3), pp. e2201968. Date of Electronic Publication: 2022 Nov 11.
DOI: 10.1002/adhm.202201968
Abstrakt: Graphene-based 2D nanomaterials possess unique physicochemical characteristics which can be utilized in various biomedical applications, including the transport and presentation of chemotherapeutic agents. In glioblastoma multiforme (GBM), intratumorally administered thin graphene oxide (GO) nanosheets demonstrate a widespread distribution throughout the tumor volume without impact on tumor growth, nor spread into normal brain tissue. Such intratumoral localization and distribution can offer multiple opportunities for treatment and modulation of the GBM microenvironment. Here, the kinetics of GO nanosheet distribution in orthotopic GBM mouse models is described and a novel nano-chemotherapeutic approach utilizing thin GO sheets as platforms to non-covalently complex a proteasome inhibitor, bortezomib (BTZ), is rationally designed. Through the characterization of the GO:BTZ complexes, a high loading capacity of the small molecule on the GO surface with sustained BTZ biological activity in vitro is demonstrated. In vivo, a single low-volume intratumoral administration of GO:BTZ complex shows an enhanced cytotoxic effect compared to free drug in two orthotopic GBM mouse models. This study provides evidence of the potential that thin and small GO sheets hold as flat nanoscale platforms for GBM treatment by increasing the bioavailable drug concentration locally, leading to an enhanced therapeutic effect.
(© 2022 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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