Obesity and Coronary Artery Disease: An Updated Systematic Review 2022.

Autor:	Manoharan MP; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Raja R; Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Jamil A; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Csendes D; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Gutlapalli SD; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Prakash K; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Swarnakari KM; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Bai M; Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Desai DM; Division of Research & Academic Affairs, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Desai A; Internal Medicine Clinical Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.; Internal Medicine, University of California Riverside School of Medicine, Riverside, USA., Penumetcha SS; General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.; General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Sep 23; Vol. 14 (9), pp. e29480. Date of Electronic Publication: 2022 Sep 23 (Print Publication: 2022).
DOI:	10.7759/cureus.29480
Abstrakt:	The primary goal is to identify the pathogenesis of cardiovascular illnesses in obese patients. Articles were extracted using the MeSH search approach from PubMed and Google Scholar databases. Inclusion and exclusion criteria were used, and duplicates were eliminated. Eight publications were finally included in this research study after two authors independently completed the quality check appraisal. Seven observational studies and one narrative review were found in our search. The publications evaluated the risk of coronary artery disease in metabolically healthy obese people with that of unhealthy obese adults and evaluated the effects of adipose tissue-mediated inflammation. Additionally, they offered several explanations for the obesity problem. Studies have indicated that adipocytokines and their pro-inflammatory cytokines have significantly affected the development of cardiovascular disease in obese subjects. The relationship between metabolically unhealthy people with increased risk for coronary artery disease (CAD) is unclear. It has also been shown that metabolically healthy obese persons are still at risk for developing coronary artery disease (CAD), as explained in certain studies in which inflammation plays a vital role in obese people. There hasn't been much data on the advantages of being physically active in overweight people, but obese people have to change their lifestyle as a first measure. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Manoharan et al.)
Databáze:	MEDLINE
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