ArVirInd-a database of arboviral antigenic proteins from the Indian subcontinent.
| Autor: | Atre NM; Bioinformatics, ICMR National Institute of Virology Pune, Pune, Maharashtra, India., Alagarasu K; Bioinformatics, ICMR National Institute of Virology Pune, Pune, Maharashtra, India., Shil P; Bioinformatics, ICMR National Institute of Virology Pune, Pune, Maharashtra, India. |
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| Jazyk: | angličtina |
| Zdroj: | PeerJ [PeerJ] 2022 Oct 21; Vol. 10, pp. e13851. Date of Electronic Publication: 2022 Oct 21 (Print Publication: 2022). |
| DOI: | 10.7717/peerj.13851 |
| Abstrakt: | Background: Studies on antigenic proteins for arboviruses are important for providing diagnostics and vaccine development. India and its neighboring countries have a huge burden of arboviral diseases. Data mining for country-specific sequences from existing bioinformatics databases is cumbersome and time-consuming. This necessitated the development of a database of antigenic proteins from arboviruses isolated from the countries of the Indian subcontinent. Methods: Arboviral antigenic protein sequences were obtained from the NCBI and other databases. In silico antigenic characterization was performed (Epitope predictions) and data was incorporated into the database. The front end was designed and developed using HTML, CSS, and PHP. For the backend of the database, we have used MySQL. Results: A database, named ArVirInd, is created as a repository of information on curated antigenic proteins. This enlists sequences by country and year of outbreak or origin of the viral strain. For each entry, antigenic information is provided along with functional sites, etc . Researchers can search this database by virus/protein name, country, and year of collection (or in combination) as well as peptide search for epitopes. It is available publicly via the Internet at http://www.arvirind.co.in. ArVirInd will be useful in the study of immune informatics, diagnostics, and vaccinology for arboviruses. Competing Interests: The authors declare there are no competing interests. (©2022 Atre et al.) |
| Databáze: | MEDLINE |
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