Multisite gynecologic endometrioid adenocarcinomas: Can mutation profiling be used to distinguish synchronous primary cancers from metastases?

Autor:	Barnes D; Department of Obstetrics and Gynecology, University of British Columbia, Canada., Mohammad N; Department of Pathology, Vancouver General Hospital and the University of British Columbia, Canada., Hoang L; Department of Pathology, Vancouver General Hospital and the University of British Columbia, Canada., Anglesio M; Department of Obstetrics and Gynecology, University of British Columbia, Canada., Hollis RL; The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, MRC Institute of Genetics and Cancer, University of Edinburgh, UK., Gourley C; The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, MRC Institute of Genetics and Cancer, University of Edinburgh, UK., Stuart HC; Department of Surgery, Vancouver General Hospital, and the University of British Columbia, Canada., Carey MS; Department of Obstetrics and Gynecology, University of British Columbia, Canada., Stuart GCE; Department of Obstetrics and Gynecology, University of British Columbia, Canada.
Jazyk:	angličtina
Zdroj:	Gynecologic oncology reports [Gynecol Oncol Rep] 2022 Oct 14; Vol. 44, pp. 101076. Date of Electronic Publication: 2022 Oct 14 (Print Publication: 2022).
DOI:	10.1016/j.gore.2022.101076
Abstrakt:	It is well recognized that some patients with endometrioid gynecological cancers have tumors arising in multiple sites (ovary, endometrium, and endometriosis) at the time of diagnosis. Molecular analysis has helped discern whether these multisite cancers represent synchronous primary tumors or alternatively metastatic disease. We present a complex case of a patient with endometrioid carcinomas arising in multiple sites. We discuss the use of mutation profiling to discern clonality and highlight how this information may inform the clinical management of such cases. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.)
Databáze:	MEDLINE
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