Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil.

Autor: Pinheiro JR; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.; Department of Biological Sciences, State University of Santa Cruz, Ilhéus 45662, BA, Brazil., Dos Reis EC; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil., Farias JP; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil., Fogaça MMC; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil., da Silva PS; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.; Department of Biological Sciences, State University of Santa Cruz, Ilhéus 45662, BA, Brazil., Santana IVR; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil., Rocha ALS; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil., Vidal PO; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil., Simões RDC; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil., Luiz WB; Department of Biological Sciences, State University of Santa Cruz, Ilhéus 45662, BA, Brazil., Birbrair A; Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte 31270, MG, Brazil.; Department of Radiology, Columbia University Medical Center, New York, NY 10032, USA., de Aguiar RS; Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte 31270, MG, Brazil.; D'Or Institute of Research, Rio de Janeiro 22281, RJ, Brazil., de Souza RP; Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte 31270, MG, Brazil., Azevedo VAC; Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte 31270, MG, Brazil., Chaves G; Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA., Belmok A; Laboratory of Baculoviruses, University of Brasilia, Brasilia 70910, DF, Brazil., Durães-Carvalho R; Department of Microbiology, Immunology and Parasitology, São Paulo School of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04023, SP, Brazil.; Post-Graduate Program in Structural and Functional Biology, UNIFESP, São Paulo 04023, SP, Brazil., Melo FL; Laboratory of Baculoviruses, University of Brasilia, Brasilia 70910, DF, Brazil., Ribeiro BM; Laboratory of Baculoviruses, University of Brasilia, Brasilia 70910, DF, Brazil., Amorim JH; Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras 47805, BA, Brazil.; Department of Biological Sciences, State University of Santa Cruz, Ilhéus 45662, BA, Brazil.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2022 Oct 21; Vol. 14 (10). Date of Electronic Publication: 2022 Oct 21.
DOI: 10.3390/v14102314
Abstrakt: Background: The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment.
Methods: In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of almost 17000 patients in 15 months. We specifically studied the fluctuations of COVID-19 cases and deaths due to COVID-19 over time according to host gender, age, viral load, and genetic variants.
Results: As the main results, we observed that the numbers of COVID-19 cases and deaths due to COVID-19 fluctuated over time and that men were the most affected by deaths, as well as those of 60 or more years old. We also observed that individuals between 30- and 44-years old were the most affected by COVID-19 cases. In addition, the viral loads in the patients' nasopharynx were higher in the early symptomatic period. We found that early pandemic SARS-CoV-2 lineages were replaced by the variant of concern (VOC) P.1 (Gamma) in the second half of the study period, which led to a significant increase in the number of deaths.
Conclusions: The results presented in this study are helpful for future formulations of efficient public policies of COVID-19 containment.
Databáze: MEDLINE
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