Novel Type of Tetranitrosyl Iron Salt: Synthesis, Structure and Antibacterial Activity of Complex [FeL' 2 (NO) 2 ][FeL'L"(NO) 2 ] with L'-thiobenzamide and L"-thiosulfate.

Autor: Sanina NA; Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia.; Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1/51 Leninskie Gory, 119991 Moscow, Russia.; Scientific and Educational Center in Chernogolovka, Medical-Biological Institute, Moscow Regional State University, 24, Vera Voloshina Street, 141014 Mytischi, Russia., Starostina AA; Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1/51 Leninskie Gory, 119991 Moscow, Russia., Utenyshev AN; Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia., Dorovatovskii PV; National Research Centre 'Kurchatov Institute', 1 Acad. Kurchatov Square, 123182 Moscow, Russia., Emel'yanova NS; Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia.; Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1/51 Leninskie Gory, 119991 Moscow, Russia., Krapivin VB; Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia., Luzhkov VB; Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia.; Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1/51 Leninskie Gory, 119991 Moscow, Russia., Mumyatova VA; Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia., Balakina AA; Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia., Terentiev AA; Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia.; Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1/51 Leninskie Gory, 119991 Moscow, Russia.; Scientific and Educational Center in Chernogolovka, Medical-Biological Institute, Moscow Regional State University, 24, Vera Voloshina Street, 141014 Mytischi, Russia., Aldoshin SM; Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia.; Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1/51 Leninskie Gory, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2022 Oct 14; Vol. 27 (20). Date of Electronic Publication: 2022 Oct 14.
DOI: 10.3390/molecules27206886
Abstrakt: In this work a new donor of nitric oxide (NO) with antibacterial properties, namely nitrosyl iron complex of [Fe(C 6 H 5 C-SNH 2 ) 2 (NO) 2 ][Fe(C 6 H 5 C-SNH 2 )(S 2 O 3 )(NO) 2 ] composition (complex I ), has been synthesized and studied. Complex I was produced by the reduction of the aqueous solution of [Fe 2 (S 2 O 3 ) 2 (NO) 2 ] 2- dianion by the thiosulfate, with the further treatment of the mixture by the acidified alcohol solution of thiobenzamide. Based on the structural study of I (X-ray analysis, quantum chemical calculations by NBO and QTAIM methods in the frame of DFT), the data were obtained on the presence of the NO…NO interactions, which stabilize the DNIC dimer in the solid phase. The conformation properties, electronic structure and free energies of complex I hydration were studied using B3LYP functional and the set of 6-31 + G(d,p) basis functions. The effect of an aquatic surrounding was taken into account in the frame of a polarized continuous model (PCM). The NO-donating activity of complex I was studied by the amperometry method using an "amiNO-700" sensor electrode of the "inNO Nitric Oxide Measuring System". The antibacterial activity of I was studied on gram-negative ( Escherichia coli ) and gram-positive ( Micrococcus luteus ) bacteria. Cytotoxicity was studied using Vero cells. Complex I was found to exhibit antibacterial activity comparable to that of antibiotics, and moderate toxicity to Vero cells.
Databáze: MEDLINE
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