Improved Mucoadhesion, Permeation and In Vitro Anticancer Potential of Synthesized Thiolated Acacia and Karaya Gum Combination: A Systematic Study.

Autor: Munot N; Technical Lead, HCL Technologies, Chennai 600058, Tamil Nadu, India., Kandekar U; Department of Pharmaceutics, Rajarshi Shahu College of Pharmacy and Research, Tathwade, Pune 411033, Maharashtra, India., Rikame C; Department of Pharmaceutics, Sinhgad Technical Education Society's Smt. Kashibai Navale College of Pharmacy, Pune 411048, Maharashtra, India., Patil A; D. Y. Patil College of Pharmacy, D. Y. Patil Education Society, Deemed to Be University, Kolhapur 416006, Maharashtra, India., Sengupta P; Physical/Material Chemistry Division, National Chemical Laboratoty (CSIR-NCL), Pashan, Pune 411008, Maharashtra, India.; Department of Chemistry, Indrashil University, Kadi 382740, Gujarat, India., Urooj S; Department of Electrical Engineering, College of Engineering, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Bilal A; Department of Food Processing & Technology, School of Vocational Studies and Applied Sciences, Gautam Buddha University, Greater Noida 201312, Uttar Pradesh, India.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2022 Oct 12; Vol. 27 (20). Date of Electronic Publication: 2022 Oct 12.
DOI: 10.3390/molecules27206829
Abstrakt: Thiolation of polymers is one of the most appropriate approaches to impart higher mechanical strength and mucoadhesion. Thiol modification of gum karaya and gum acacia was carried out by esterification with 80% thioglycolic acid. FTIR, DSC and XRD confirmed the completion of thiolation reaction. Anticancer potential of developed thiomer was studied on cervical cancer cell lines (HeLa) and more than 60% of human cervical cell lines (HeLa) were inhibited at concentration of 5 µg/100 µL. Immobilized thiol groups were found to be 0.8511 mmol/g as determined by Ellman's method. Cytotoxicity studies on L929 fibroblast cell lines indicated thiomers were biocompatible. Bilayered tablets were prepared using Ivabradine hydrochloride as the model drug and synthesized thiolated gums as mucoadhesive polymer. Tablets prepared using thiolated polymers in combination showed more swelling, mucoadhesion and residence time as compared to unmodified gums. Thiol modification controlled the release of the drug for 24 h and enhanced permeation of the drug up to 3 fold through porcine buccal mucosa as compared to tablets with unmodified gums. Thiolated polymer showed increased mucoadhesion and permeation, anticancer potential, controlled release and thus can be utilized as a novel excipient in formulation development.
Databáze: MEDLINE
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