| Autor: |
Dragasevic S; Clinic for Gastroenterology and Hepatology, University Clinical Center Serbia, Koste Todorovica Street 2, 11000 Belgrade, Serbia.; Faculty of medicine, University of Belgrade, Pasterova Street 2, 11000 Belgrade, Serbia., Stankovic B; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe Street 444A, 11042 Belgrade, Serbia., Kotur N; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe Street 444A, 11042 Belgrade, Serbia., Milutinovic AS; Clinic for Gastroenterology and Hepatology, University Clinical Center Serbia, Koste Todorovica Street 2, 11000 Belgrade, Serbia.; Faculty of medicine, University of Belgrade, Pasterova Street 2, 11000 Belgrade, Serbia., Milovanovic T; Clinic for Gastroenterology and Hepatology, University Clinical Center Serbia, Koste Todorovica Street 2, 11000 Belgrade, Serbia.; Faculty of medicine, University of Belgrade, Pasterova Street 2, 11000 Belgrade, Serbia., Stojkovic Lalosevic M; Clinic for Gastroenterology and Hepatology, University Clinical Center Serbia, Koste Todorovica Street 2, 11000 Belgrade, Serbia.; Faculty of medicine, University of Belgrade, Pasterova Street 2, 11000 Belgrade, Serbia., Stojanovic M; Faculty of medicine, University of Belgrade, Pasterova Street 2, 11000 Belgrade, Serbia.; Clinic for Allergy and Immunology, University Clinical Center of Serbia, Koste Todorovic Street 2, 11000 Belgrade, Serbia., Pavlovic S; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe Street 444A, 11042 Belgrade, Serbia., Popovic D; Clinic for Gastroenterology and Hepatology, University Clinical Center Serbia, Koste Todorovica Street 2, 11000 Belgrade, Serbia.; Faculty of medicine, University of Belgrade, Pasterova Street 2, 11000 Belgrade, Serbia. |
| Abstrakt: |
Inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are complex diseases whose etiology is associated with genetic and environmental risk factors, among which are diet and gut microbiota. To date, IBD is an incurable disease and the main goal of its treatment is to reduce symptoms, prevent complications, and improve nutritional status and the quality of life. Patients with IBD usually suffer from nutritional deficiency with imbalances of specific micronutrient levels that contribute to the further deterioration of the disease. Therefore, along with medications usually used for IBD treatment, therapeutic strategies also include the supplementation of micronutrients such as vitamin D, folic acid, iron, and zinc. Micronutrient supplementation tailored according to individual needs could help patients to maintain overall health, avoid the triggering of symptoms, and support remission. The identification of individuals' genotypes associated with the absorption, transport and metabolism of micronutrients can modify future clinical practice in IBD and enable individualized treatment. This review discusses the personalized approach with respect to genetics related to micronutrients commonly used in inflammatory bowel disease treatment. |
