| Autor: |
Filev R; Department of Nephrology, Internal Disease Clinic, University Hospital 'Saint Anna', 1750 Sofia, Bulgaria.; Medical Faculty, Medical University Sofia, 1431 Sofia, Bulgaria., Rostaing L; Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, Grenoble University Hospital, 38700 Grenoble, France.; Grenoble Alpes University, 38400 Grenoble, France., Lyubomirova M; Department of Nephrology, Internal Disease Clinic, University Hospital 'Saint Anna', 1750 Sofia, Bulgaria.; Medical Faculty, Medical University Sofia, 1431 Sofia, Bulgaria., Bogov B; Department of Nephrology, Internal Disease Clinic, University Hospital 'Saint Anna', 1750 Sofia, Bulgaria.; Medical Faculty, Medical University Sofia, 1431 Sofia, Bulgaria., Kalinov K; Head Biometrics Group, Comac-Medical Ltd., 1404 Sofia, Bulgaria., Svinarov D; Medical Faculty, Medical University Sofia, 1431 Sofia, Bulgaria.; Department of Clinical Laboratory, University Hospital 'Alexandrovska', 1431 Sofia, Bulgaria. |
| Abstrakt: |
Regarding COVID-19 infection, Bulgaria has one of the lowest rates of vaccination in Europe, and its COVID-19-related mortality rate has been one of the highest in the European Union. Chronic kidney disease (CKD)-COVID-19 patients are at higher risk of developing acute kidney injury (AKI) and death after hospital admission. This single-center prospective cohort study from Bulgaria included 120 in-patient COVID-19 subjects of whom 70 had CKD and 50 normal renal function. Diabetes mellitus, hypertension, obesity, and cardiovascular disease were statistically more prevalent in the CKD group as compared to the non-CKD group. At admission, D-dimer, creatinine, and urea levels were significantly higher in the CKD group, whereas estimated glomerular-filtration rate was significantly lower as compared to the non-CKD patients. During hospitalization, 23 patients (19.1%) died, of which 19 were in the CKD group ( p -value = 0.0096); in addition, 38 developed AKI (31.6%), of which 31 were in the CKD group ( p -value = 0.0006). Using binary logistic regression, being male, having experienced AKI, and not having been treated with remdesivir were independent risk factors for COVID-19-induced mortality. Regarding risk of AKI, having had COVID-19-related symptoms for more than 6 days before admission, having CKD at baseline, and having not received remdesivir therapy were independent predictive factors for developing AKI after admission. |
