Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population.

Autor: Abreu-Glowacka M; Department of Forensic Medicine, Poznan University of Medical Sciences, 60-781 Poznan, Poland., Pepinski W; Department of Forensic Medicine, Medical University of Bialystok, 15-269 Bialystok, Poland., Michalak E; Department of Forensic Medicine, Poznan University of Medical Sciences, 60-781 Poznan, Poland., Konarzewska M; Department of Forensic Medicine, Medical University of Warsaw, 02-007 Warsaw, Poland., Zak K; Department of Forensic Medicine, Medical University of Warsaw, 02-007 Warsaw, Poland., Skawronska M; Department of Forensic Medicine, Medical University of Bialystok, 15-269 Bialystok, Poland., Niemcunowicz-Janica A; Department of Forensic Medicine, Medical University of Bialystok, 15-269 Bialystok, Poland., Soltyszewski I; Department of Forensic Medicine, Medical University of Warsaw, 02-007 Warsaw, Poland., Krajewski P; Department of Forensic Medicine, Medical University of Warsaw, 02-007 Warsaw, Poland., Zaba C; Department of Forensic Medicine, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Jazyk: angličtina
Zdroj: Genes [Genes (Basel)] 2022 Sep 20; Vol. 13 (10). Date of Electronic Publication: 2022 Sep 20.
DOI: 10.3390/genes13101683
Abstrakt: (1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 autosomal polymorphic InDel loci included in the Investigator DIPplex kit (Qiagen) were obtained in a sample of 631 unrelated Polish individuals. Allelic frequency data were compared with those reported for selected populations (3) Results: All the loci conformed with Hardy-Weinberg equilibrium after applying a Bonferroni correction and no pair-wise significant linkage disequilibrium was detected. (4) Conclusions: DIPplex Kit differences were high among populations worldwide. The InDel markers are highly discriminating for human identification purposes in the Polish population.
Databáze: MEDLINE
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