Açaí ( Euterpe oleracea Mart.) Attenuates Oxidative Stress and Alveolar Bone Damage in Experimental Periodontitis in Rats.

Autor:	Dos Santos VRN; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Frazão DR; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Ferreira RO; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Mendes PFS; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Baia-da-Silva DC; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Souza-Monteiro D; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Bittencourt LO; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., de Moura JDM; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Perdigão JM; Center for Valorization of Amazonian Bioactive Compounds, College of Biotechnology, Federal University of Pará, Belém 66075-110, PA, Brazil., Teixeira BJB; Center for Valorization of Amazonian Bioactive Compounds, College of Biotechnology, Federal University of Pará, Belém 66075-110, PA, Brazil., Varela ELP; Oxidative Stress Research Laboratory and Post-Graduate Program in Biodiversity and Biotecnology of the BIONORTE Network, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Balbinot GS; Dental Materials Laboratory, Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Percário S; Oxidative Stress Research Laboratory and Post-Graduate Program in Biodiversity and Biotecnology of the BIONORTE Network, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Rogez H; Center for Valorization of Amazonian Bioactive Compounds, College of Biotechnology, Federal University of Pará, Belém 66075-110, PA, Brazil., Rösing CK; Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Collares FM; Dental Materials Laboratory, Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Lima RR; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
Jazyk:	angličtina
Zdroj:	Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2022 Sep 26; Vol. 11 (10). Date of Electronic Publication: 2022 Sep 26.
DOI:	10.3390/antiox11101902
Abstrakt:	Açaí ( Euterpe oleracea Mart.) juice is rich in phenolic compounds with high antioxidant capacity. It has been observed that the use of antioxidants may be an additional strategy to nonsurgical periodontal therapy as well as to prevent alveolar bone loss. Thus, the objective of this study was to investigate the effects of açaí supplementation on experimental periodontitis in rats. Twenty male Rattus norvegicus (Wistar) rats were assigned into control, açaí, experimental periodontitis, and experimental periodontitis with açaí supplementation groups. Periodontitis was induced by placing ligatures around the lower first molars. Animals in the açaí groups received 0.01 mL/g of clarified açaí juice for 14 days by intragastric gavage. At the end of the experimental period, blood was collected to assess the reduced glutathione (GSH), Trolox equivalent antioxidant capacity (TEAC), and lipid peroxidation (TBARS) levels. Moreover, hemimandibles were analyzed by micro-computed tomography (micro-CT) for alveolar bone loss and bone quality. Açaí supplementation increased blood total antioxidant capacity and decreased lipid peroxidation. It also reduced alveolar bone loss when compared to the experimental periodontitis group. Moreover, clarified açaí per se modulated the oxidative biochemistry and bone microstructure. Thus, açaí may be considered a viable alternative for managing periodontal oxidative stress and preventing alveolar bone loss.
Databáze:	MEDLINE
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