Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex.

Autor: Razza LB; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.; Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, 9000 Ghent, Belgium., da Silva PHR; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil., Busatto GF; Laboratório de Neuroimagem em Psiquiatria (LIM-21), Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Ovidio Pires de Campos 785, São Paulo 05403-000, Brazil., Duran FLS; Laboratório de Neuroimagem em Psiquiatria (LIM-21), Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Ovidio Pires de Campos 785, São Paulo 05403-000, Brazil., Pereira J; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil., De Smet S; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.; Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, 9000 Ghent, Belgium., Klein I; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil., Zanão TA; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil., Luethi MS; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil., Baeken C; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.; Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, 9000 Ghent, Belgium.; Department of Psychiatry (UZBrussel), Free University Brussels, 1090 Brussels, Belgium.; Department of Electrical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.; Department of Experimental Clinical and Health Psychology, Ghent University, 9000 Ghent, Belgium., Vanderhasselt MA; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.; Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, 9000 Ghent, Belgium., Buchpiguel CA; Divisão de Medicina Nuclear (LIM-43), Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-904, Brazil., Brunoni AR; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.; Laboratório de Neuroimagem em Psiquiatria (LIM-21), Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Ovidio Pires de Campos 785, São Paulo 05403-000, Brazil.; Departamento de Clínica Médica, Faculdade de Medicina da Universidade de São Paulo & Hospital Universitário, Universidade de São Paulo, Av. Prof Lineu Prestes 2565, São Paulo 05508-000, Brazil.; Hospital Universitário, Universidade de São Paulo, São Paulo 01246-904, Brazil.
Jazyk: angličtina
Zdroj: Biomedicines [Biomedicines] 2022 Sep 27; Vol. 10 (10). Date of Electronic Publication: 2022 Sep 27.
DOI: 10.3390/biomedicines10102410
Abstrakt: Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required.
Databáze: MEDLINE