SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19.

Autor:	Beckman D; California National Primate Research Center, University of California Davis, Davis, CA 95616, USA., Bonillas A; California National Primate Research Center, University of California Davis, Davis, CA 95616, USA., Diniz GB; California National Primate Research Center, University of California Davis, Davis, CA 95616, USA., Ott S; California National Primate Research Center, University of California Davis, Davis, CA 95616, USA., Roh JW; Center for Immunology and Infectious Diseases, University of California Davis, Davis, CA 95616, USA; Graduate Group in Immunology, University of California Davis, Davis, CA 95616, USA., Elizaldi SR; Center for Immunology and Infectious Diseases, University of California Davis, Davis, CA 95616, USA; Graduate Group in Immunology, University of California Davis, Davis, CA 95616, USA., Schmidt BA; Center for Immunology and Infectious Diseases, University of California Davis, Davis, CA 95616, USA., Sammak RL; California National Primate Research Center, University of California Davis, Davis, CA 95616, USA., Van Rompay KKA; California National Primate Research Center, University of California Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA., Iyer SS; California National Primate Research Center, University of California Davis, Davis, CA 95616, USA; Center for Immunology and Infectious Diseases, University of California Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA., Morrison JH; California National Primate Research Center, University of California Davis, Davis, CA 95616, USA; Department of Neurology, School of Medicine, University of California Davis, Davis, CA 95616, USA. Electronic address: jhmorrison@ucdavis.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2022 Nov 01; Vol. 41 (5), pp. 111573. Date of Electronic Publication: 2022 Oct 12.
DOI:	10.1016/j.celrep.2022.111573
Abstrakt:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), can induce a plethora of neurological complications in some patients. However, it is still under debate whether SARS-CoV-2 directly infects the brain or whether CNS sequelae result from systemic inflammatory responses triggered in the periphery. By using high-resolution microscopy, we investigated whether SARS-CoV-2 reaches the brain and how viral neurotropism can be modulated by aging in a non-human primate model of COVID-19. Seven days after infection, SARS-CoV-2 was detected in the olfactory cortex and interconnected regions and was accompanied by robust neuroinflammation and neuronal damage exacerbated in aged, diabetic animals. Our study provides an initial framework for identifying the molecular and cellular mechanisms underlying SARS-CoV-2 neurological complications, which will be essential to reducing both the short- and long-term burden of COVID-19. Competing Interests: Declaration of interests The authors declare that they have no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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