| Autor: |
Raju S; Department of Medicine and., Woo H; Department of Medicine and., Koehler K; Department of Environmental Health Sciences and Engineering and., Fawzy A; Department of Medicine and., Liu C; Department of Medicine and., Putcha N; Department of Medicine and., Balasubramanian A; Department of Medicine and., Peng RD; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Lin CT; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Lemoine C; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and., Wineke J; Department of Psychiatry, University of Maryland Medical Center, Baltimore, Maryland., Berger RD; Department of Medicine and., Hansel NN; Department of Medicine and.; Department of Environmental Health Sciences and Engineering and., McCormack MC; Department of Medicine and.; Department of Environmental Health Sciences and Engineering and. |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2023 Mar 15; Vol. 207 (6), pp. 721-730. |
| DOI: |
10.1164/rccm.202203-0523OC |
| Abstrakt: |
Rationale: Indoor air pollution represents a modifiable risk factor for respiratory morbidity in chronic obstructive pulmonary disease (COPD). The effects of indoor air pollution, as well as the impact of interventions to improve indoor air quality, on cardiovascular morbidity in COPD remain unknown. Objectives: To determine the association between indoor particulate matter (PM) and heart rate variability (HRV), a measure of cardiac autonomic function tied to cardiovascular morbidity and mortality, as well as the impact of household air purifiers on HRV. Methods: Former smokers with moderate-severe COPD were recruited from a 6-month randomized controlled trial of a portable air cleaner intervention to undergo paired assessment of both in-home PM and HRV using 24-hour Holter monitoring at up to five time points. Primary outcomes were HRV measures tied to cardiovascular morbidity (standard deviation of normal-to-normal intervals [SDNN] and root mean square of successive differences between normal-to-normal intervals [RMSSD]). Measurements and Results: Eighty-five participants contributed 317 HRV measurements. A twofold increase in household PM ⩽2.5 µm in aerodynamic diameter was associated with decreases in SDNN (β, -2.98% [95% confidence interval (CI), -5.12 to -0.78]) and RMSSD (β, -4.57% [95% CI, -10.1 to -1.60]). The greatest effects were observed with ultrafine particles (<100 nm) (RMSSD; β, -16.4% [95% CI, -22.3 to -10.1]) and among obese participants. Participants randomized to the active air cleaner saw improvements in RMSSD (β, 25.2% [95% CI, 2.99 to 52.1]), but not SDNN (β, 2.65% [95% CI, -10.8 to 18.1]), compared with the placebo group. Conclusions: This is the first U.S. study to describe the association between household PM and cardiac autonomic function among individuals with COPD, as well as the potential cardiovascular health benefits of household air cleaners. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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