Crimean-Congo Hemorrhagic Fever Virus Survey in Humans, Ticks, and Livestock in Agnam (Northeastern Senegal) from February 2021 to March 2022.

Autor: Mhamadi M; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal.; Parasitology Department, Université Cheikh Anta Diop de Dakar, Dakar 10700, Senegal., Badji A; Institut Pasteur de Dakar, Medical Zoology Department, Dakar 12900, Senegal., Dieng I; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal., Gaye A; Institut Pasteur de Dakar, Medical Zoology Department, Dakar 12900, Senegal., Ndiaye EH; Institut Pasteur de Dakar, Medical Zoology Department, Dakar 12900, Senegal., Ndiaye M; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal., Mhamadi M; Institut Pasteur de Dakar, DIATROPIX, Dakar 12900, Senegal., Touré CT; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal., Mbaye MR; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal., Barry MA; Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Science Department, Dakar 12900, Senegal., Ndiaye O; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal.; Institut Pasteur de Dakar, DIATROPIX, Dakar 12900, Senegal., Faye B; Parasitology Department, Université Cheikh Anta Diop de Dakar, Dakar 10700, Senegal., Ba FA; Microbiology, Immunology and Infectious Pathology Service, Department of Public Health and Environment, EISMV of Dakar, Dakar 12900, Senegal., Diop B; Ministry of Health and Social Action, Dakar 12900, Senegal., Ndiaye M; Ministry of Health and Social Action, Dakar 12900, Senegal., Fall M; Ministry of Livestock and Animal Production, Dakar 12900, Senegal., Sagne SN; Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Science Department, Dakar 12900, Senegal., Fall G; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal., Loucoubar C; Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Science Department, Dakar 12900, Senegal., Fausther-Bovendo H; Global Urgent and Advanced Research and Development, Batiscan, QC G0X 1A0, Canada., Sall AA; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal., Kobinger G; University of Texas Medical Branch, Galveston, TX 77555-0132, USA., Faye O; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal., Diallo M; Institut Pasteur de Dakar, Medical Zoology Department, Dakar 12900, Senegal., Faye O; Institut Pasteur de Dakar, Virology Department, Dakar 12900, Senegal.
Jazyk: angličtina
Zdroj: Tropical medicine and infectious disease [Trop Med Infect Dis] 2022 Oct 21; Vol. 7 (10). Date of Electronic Publication: 2022 Oct 21.
DOI: 10.3390/tropicalmed7100324
Abstrakt: Crimean-Congo hemorrhagic fever virus (CCHFV) is widespread in Asia, Europe, and Africa. In Senegal, sporadic cases of CCHFV have been reported since 1960. Bordering Mauritania in northeastern Senegal, Agnam is an arid area in the region of Matam where CCHFV is endemic, which harbors a pastoralist community. Given the drought conditions of Agnam, inhabitants are in constant movement with their animals in search of pasture, which brings them into contact with pathogens such as arboviruses. To identify CCHFV in this area, we established a One Health site in order to analyze animal livestock, ticks and human samples collected over a one-year period by qRT-PCR and ELISA. Our analysis showed one (1/364) patient carried anti-CCHFV IgM and thirty-seven carried anti-CCHFV IgG (37/364). In livestock, anti-CCHFV IgG was detected in 13 (38.24%) of 34 sentinel sheep. The risk of CCHFV infection increased significatively with age in humans ( p -value = 0.00117) and sheep ( p -value = 1.18 × 10 -11 ). Additional risk factors for CCHFV infection in sheep were dry seasons ( p -value = 0.004) and time of exposure ( p -value = 0.007). Furthermore, we detected a total of three samples with CCHFV RNA within Rhipicephalus evertsi evertsi and Rhipicephalus guilhoni tick species. Our results highlighted the usefulness of a One Health survey of CCHFV in pastoral communities at risk of arboviruses.
Databáze: MEDLINE
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