| Autor: |
Andrews FV; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA.; Oregon Clinical and Translational Research Institute, Oregon Health and Sciences University, Portland, OR 97239, USA., Branscum A; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA., Hystad P; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA., Smit E; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA., Afroz S; Dhaka Community Hospital Trust, Dhaka 1217, Bangladesh., Golam M; Dhaka Community Hospital Trust, Dhaka 1217, Bangladesh., Sharif O; Dhaka Community Hospital Trust, Dhaka 1217, Bangladesh., Rahman M; Dhaka Community Hospital Trust, Dhaka 1217, Bangladesh., Quamruzzaman Q; Dhaka Community Hospital Trust, Dhaka 1217, Bangladesh., Christiani DC; Harvard T.H. Chan School of Public Health, Department of Environmental Health, Harvard University, Boston, MA 02115, USA., Kile ML; School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA. |
| Abstrakt: |
(1) Background: Arsenic (As) is a common drinking water contaminant that is regulated as a carcinogen. Yet, As is a systemic toxicant and there is considerable epidemiological data showing As adversely impacts reproductive health. This study used data from a birth cohort in Bangladesh (2008−2011) to examine associations between drinking water As levels and reproductive outcomes. (2) Methods: Pregnant individuals (n = 1597) were enrolled at <16 weeks gestation and drinking water As was measured. Participants with live births (n = 1130) were propensity score matched to participants who experienced miscarriage (n = 132), stillbirth (n = 72), preterm birth (n = 243), and neonatal mortality (n = 20). Logistic regression was used to examine drinking water As recommendations of 50, 10, 5, 2.5, and 1 µg/L on the odds of adverse birth outcomes. (3) Results: The odds of miscarriage were higher for pregnant women exposed to drinking water ≥2.5 versus <2.5 µg As/L [adjusted odds ratio (OR) 1.90, 95% Confidence Interval (CI): 1.07−3.38)]. (4) Conclusions: These preliminary findings suggest a potential threshold where the odds of miscarriage increases when drinking water As is above 2.5 µg/L. This concentration is below the World Health Organizations and Bangladesh’s drinking water recommendations and supports the re-evaluation of drinking water regulations. |
