[ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis].

Autor:	Arutyunov GP; Eurasian Association of Therapists.; Pirogov Russian National Research Medical University., Tarlovskaya EI; Eurasian Association of Therapists.; Privolzhsky Research Medical University., Arutyunov AG; Eurasian Association of Therapists.; Pirogov Russian National Research Medical University., Belenkov YN; Sechenov First Moscow State Medical University (Sechenov University)., Konradi AO; Almazov National Medical Research Centre., Lopatin YM; Volgograd State Medical University., Rebrov AP; Saratov State Medical University named after V.I. Razumovsky., Tereshchenko SN; National Medical Research Center of Cardiology., Chesnikova AI; Rostov State Medical University., Hayrapetyan HG; 'Erebouni' Cardiology Center., Babin AP; Nicolae Testemitanu State University of Medicine and Pharmacy., Bakulin IG; Mechnikov North-Western State Medical University., Bakulina NV; Mechnikov North-Western State Medical University., Balykova LA; Ogarev Mordovia State University., Blagonravova AS; Privolzhsky Research Medical University., Boldina MV; Privolzhsky Research Medical University., Vaisberg AR; Privolzhsky Research Medical University., Galyavich AS; Republican Center for Cardiovascular Diseases of Interregional Clinical Diagnostic Center.; Kazan State Medical University., Gomonova VV; Mechnikov North-Western State Medical University., Grigorieva NY; Lobachevsky State University., Gubareva IV; Samara State Medical University., Demko IV; Regional Clinical Hospital., Evzerikhina AV; Krasnogorsk City Hospital №1., Zharkov AV; Kirovsk Interdisrict Hospital., Kamilova UK; Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation., Kim ZF; City Clinical Hospital №7., Kuznetsova TY; Petrozavodsk State University., Lareva NV; Chita State Medical Academy., Makarova EV; Privolzhsky Research Medical University., Malchikova SV; Kirov State Medical University., Nedogoda SV; Volgograd State Medical University., Petrova MM; Voino-Yasenetsky Krasnoyarsk State Medical University., Pochinka IG; Privolzhsky Research Medical University.; City Clinical Hospital №13 of., Protasov KV; Irkutsk State Medical Academy of Postgraduate Education - Branch of Russian Medical Academy of Continuous Professional Education., Protsenko DN; Moscow City Clinical Hospital №40., Ruzanau DY; Gomel State Medical University., Sayganov SA; Mechnikov North-Western State Medical University., Sarybaev AS; Mirrakhimov National Center of Cardiology and Therapy., Selezneva NM; Ogarev Mordovia State University., Sugraliev AB; Asfendiyarov Kazakh National Medical University., Fomin IV; Privolzhsky Research Medical University., Khlynova OV; Vagner Perm State Medical University., Chizhova OY; Mechnikov North-Western State Medical University., Shaposhnik II; South Ural State Medical University., Sh'ukarev DA; Kirovsk Interdisrict Hospital., Abdrahmanova АK; Kazakh Medical University of Continuing Education.; Zhekenovа City Clinical Infectious Diseases Hospital., Avetisian SA; 'Erebouni' Cardiology Center., Avoyan HG; 'Erebouni' Cardiology Center., Azarian KK; 'Erebouni' Cardiology Center., Aimakhanova GT; Asfendiyarov Kazakh National Medical University., Ayipova DA; Mirrakhimov National Center of Cardiology and Therapy., Akunov AC; Mirrakhimov National Center of Cardiology and Therapy., Alieva MK; Mechnikov North-Western State Medical University., Aparkina AV; Razumovsky Saratov State Medical University., Aruslanova OR; Clinical Cardiological Dispensary., Ashina EY; Privolzhsky Research Medical University., Badina OY; The Volga District Medical Centre., Barisheva OY; Petrozavodsk State University., Batchayeva AS; Pirogov Russian National Research Medical University., Bitieva AM; Mechnikov North-Western State Medical University., Bikhteyev IU; Mechnikov North-Western State Medical University., Borodulina NA; Clinical Cardiological Dispensary., Bragin MV; Mechnikov North-Western State Medical University., Budu AM; City Clinical Hospital №1., Bykova GM; Vagner Perm State Medical University., Vagapova KR; Polyclinic №1 of the President of the Russian Federation., Varlamova DD; Petrozavodsk State University., Vezikova NN; Petrozavodsk State University., Verbitskaya EA; Voino-Yasenetsky Krasnoyarsk State Medical University., Vilkova OE; Lobachevsky State University., Vinnikova EA; Mechnikov North-Western State Medical University., Vustina VV; Perm Regional Clinical Hospital., Galova EA; Privolzhsky Research Medical University., Genkel VV; South Ural State Medical University., Gorshenina EI; Ogarev Mordovia State University., Gostishev RV; Moscow City Clinical Hospital №40., Grigorieva EV; Saratov State Medical University named after V.I. Razumovsky., Gubareva EY; Samara State Medical University., Dabylova GM; Asfendiyarov Kazakh National Medical University., Demchenko AI; Samara State Medical University., Dolgikh OY; Chapaevskaya Central City Hospital., Duyshobayev MY; Mirrakhimov National Center of Cardiology and Therapy., Evdokimov DS; Mechnikov North-Western State Medical University., Egorova KE; Baranov Republic Hospital., Ermilova AN; Eurasian Association of Therapists.; Serbsky National Medical Research Centre for Psychiatry and Narcology., Zheldybayeva AE; Asfendiyarov Kazakh National Medical University., Zarechnova NV; The Volga District Medical Centre., Zimina YD; City Clinical Hospital №25., Ivanova SY; Hospital for Veterans., Ivanchenko EY; Privolzhsky Research Medical University., Ilina MV; Polyclinic of Kirovsk Interdistrict Hospital., Kazakovtseva MV; Kirov State Medical University., Kazymova EV; Clinical Hospital RZhD Meditsyna., Kalinina YS; Voino-Yasenetsky Krasnoyarsk State Medical University., Kamardina NA; The Volga District Medical Centre., Karachenova AM; Chita State Medical Academy, Chita., Karetnikov IA; Irkutsk Regional Сlinical Рospital., Karoli NA; Saratov State Medical University named after V.I. Razumovsky., Karsiev MK; Mechnikov North-Western State Medical University., Кaskaeva DS; Voino-Yasenetsky Krasnoyarsk State Medical University., Kasymova KF; Voino-Yasenetsky Krasnoyarsk State Medical University., Kerimbekova ZB; Mirrakhimov National Center of Cardiology and Therapy., Kerimova AS; Moscow City Clinical Hospital №40., Kim ES; Kazan State Medical University.; City Clinical Hospital №7., Kiseleva NV; Privolzhsky Research Medical University., Klimenko DA; Samara State Medical University., Klimova AV; Moscow City State Outpatient Hospital №134.; Pirogov Russian National Research Medical University., Kovalishena OV; Privolzhsky Research Medical University., Kolmakova EV; Mechnikov North-Western State Medical University., Kolchinskaya TP; City Clinical Hospital №1., Kolyadich MI; South Ural State Medical University.; City Clinical Hospital №1., Kondriakova OV; Samara State Medical University., Konoval MP; Mechnikov North-Western State Medical University., Konstantinov DY; Samara State Medical University., Konstantinova EA; Samara State Medical University., Kordukova VA; Privolzhsky Research Medical University., Koroleva EV; City Сlinical Рospital №5., Kraposhina AY; Regional Clinical Hospital.; Voino-Yasenetsky Krasnoyarsk State Medical University., Kriukova TV; Association 'Eurasian Association of Therapists'., Kuznetsova AS; South Ural State Medical University., Kuzmina TY; Voino-Yasenetsky Krasnoyarsk State Medical University., Kuzmichev KV; City Clinical Hospital №13 of Nizhnii Novgorod., Kulchoroevna CK; Mirrakhimov National Center of Cardiology and Therapy., Kuprina TV; Petrozavodsk State University., Kouranova IM; Gorodetskaya Central District Hospital., Kurenkova LV; Katkov Republic Clinical Hospital., Kurchugina NY; Samara State Medical University., Kushubakova NA; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Levankova VI; City Polyclinic №1., Lyubavina NA; Privolzhsky Research Medical University., Magdeyeva NA; Razumovsky Saratov State Medical University., Mazalov KV; The Volga District Medical Centre., Majseenko VI; Gomel State Medical University., Makarova AS; Irkutsk State Medical Academy of Postgraduate Education - Branch of Russian Medical Academy of Continuous Professional Education., Maripov AM; Mirrakhimov National Center of Cardiology and Therapy., Marusina AA; Polyclinic of Kirovsk Interdistrict Hospital., Melnikov ES; Eurasian Association of Therapists.; Mechnikov North-Western State Medical University., Moiseenko NB; Lobachevsky State University., Muradova FN; Privolzhsky Research Medical University., Muradyan RG; Global Medical System Clinics and Hospitals., Musaelian SN; Yerevan State Medical University., Myshak AO; Group of companies 'Medinvestgroup'., Nekaeva ES; Privolzhsky Research Medical University., Nikitina NM; Razumovsky Saratov State Medical University., Ogurlieva BB; Pirogov Russian National Research Medical University.; Moscow City Clinical Hospital №4., Odegova AA; Kirov State Medical University., Omarova YV; Privolzhsky Research Medical University., Omurzakova NA; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Ospanova SO; Asfendiyarov Kazakh National Medical University., Pahomova EV; Republican tuberculosis dispensary., Petrov LD; Health Center of Brichen., Plastinina SS; Privolzhsky Research Medical University., Pogrebetskaya VA; City Clinical Hospital №38., Polyakov DS; Privolzhsky Research Medical University., Ponomarenko EV; Medical center 'Zimamed'., Popova LL; Samara State Medical University., Prokofeva NA; Mechnikov North-Western State Medical University., Pudova IA; Privolzhsky Research Medical University.; Nizhniy Novgorod city Outpatient Hospital №4., Rakov NA; Privolzhsky Research Medical University., Rahimov AN; Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation., Rozanova NA; Krasnogorsk city hospital №1., Serikbolkyzy S; Asfendiyarov Kazakh National Medical University., Simonov AA; Mechnikov North-Western State Medical University., Skachkova VV; Perm Regional Clinical Hospital., Soloveva DV; Privolzhsky Research Medical University., Soloveva IA; Regional Clinical Hospital.; Voino-Yasenetsky Krasnoyarsk State Medical University., Subbotin AK; The Volga District Medical Centre., Sukhomlinova IM; Hospital for Veterans., Sushilova AG; Mechnikov North-Western State Medical University., Tagayeva DR; Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation., Titojkina YV; Ogarev Mordovia State University., Tikhonova EP; Voino-Yasenetsky Krasnoyarsk State Medical University., Tokmin DS; Labs of the Future., Tolmacheva AA; Novosibirsk State Medical University.; Clinical Counselling and Diagnostic Polyclinic., Torgunakova MS; Voino-Yasenetsky Krasnoyarsk State Medical University., Trenogina KV; Perm Regional Clinical Hospital., Trostianetckaia NA; Mechnikov North-Western State Medical University., Trofimov DA; Kazan State Medical University.; City Clinical Hospital №7., Tulichev AA; Privolzhsky Research Medical University.; SBHI of Nizhniy Novgorod region City Clinical Hospital №3., Tursunova AT; Asfendiyarov Kazakh National Medical University., Ulanova ND; City Clinical Hospital №13 of Nizhnii Novgorod., Fatenkov OV; Samara State Medical University., Fedorishina OV; Irkutsk State Medical Academy of Postgraduate Education - Branch of Russian Medical Academy of Continuous Professional Education., Fil TS; Mechnikov North-Western State Medical University., Fomina IY; Privolzhsky Research Medical University.; SBHI of Nizhniy Novgorod region City Outpatient Hospital №1., Fominova IS; Ogarev Mordovia State University., Frolova IA; The Volga District Medical Centre., Tsvinger SM; Chita State Medical Academy of Medicine., Tsoma VV; Volgograd State Medical University., Cholponbaeva MB; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Chudinovskikh TI; Kirov State Medical University., Shevchenko OA; Samara City Polyclinic №3., Sheshina TV; Lobachevsky State University., Shishkina EA; Perm State Medical University named after E.A. Vagner., Shishkov KY; Samara State Medical University., Sherbakov SY; Kazan State Medical Academy - Branch of the Russian Medical Academy of Continuous Professional Education., Yausheva EA; Ogarev Mordovia State University.
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2022 Jan 15; Vol. 94 (1), pp. 32-47. Date of Electronic Publication: 2022 Jan 15.
DOI:	10.26442/00403660.2022.01.201320
Abstrakt:	Aim: Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection. Materials and Methods: The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home. Clinicaltrials: gov ID NCT04492384. Results: Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively. Conclusion: Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.
Databáze:	MEDLINE
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