| Autor: |
Runova GE; Sechenov First Moscow State Medical University (Sechenov University)., Golounina OO; Sechenov First Moscow State Medical University (Sechenov University)., Glinkina IV; Sechenov First Moscow State Medical University (Sechenov University)., Fadeev VV; Sechenov First Moscow State Medical University (Sechenov University). |
| Jazyk: |
ruština |
| Zdroj: |
Terapevticheskii arkhiv [Ter Arkh] 2021 Oct 15; Vol. 93 (10), pp. 1221-1226. Date of Electronic Publication: 2021 Oct 15. |
| DOI: |
10.26442/00403660.2021.10.201081 |
| Abstrakt: |
Primary hyperparathyroidism (PHPT) is the third most common endocrine disease after diabetes mellitus and thyroid pathology. Recent epidemiological and experimental data have shown that long-term maintenance of low vitamin D levels in the blood can lead to the development of hyperplastic processes in the cells of the parathyroid glands, followed by autonomous production of parathyroid hormone. In PHPT vitamin D insufficiency or deficiency according to various sources occurs with a frequency of 5377% of cases. The literature review indicates more severe disease in patients with concomitant vitamin D deficiency. The expediency of preoperative assessment of vitamin D levels in all patients with PHPT in order to minimize the risk of hypocalcemia after parathyroidectomy is discussed. This article presents the relationship between vitamin D deficiency and PHPT, as well as possible methods for correcting vitamin D deficiency in PHPT. Molecular and cellular mechanisms of the occurrence of pathological processes in the parathyroid glands under conditions of low vitamin D levels are presented. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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