[Efficacy and safety of bulevirtide in patients with chronic hepatitis D and compensated cirrhosis].

Autor:	Bogomolov PO; Vladimirsky Moscow Regional Research Clinical Institute.; Yevdokimov Moscow State University of Medicine and Dentistry., Ivashkin VT; Sechenov First Moscow State Medical University (Sechenov University)., Bueverov AO; Vladimirsky Moscow Regional Research Clinical Institute.; Sechenov First Moscow State Medical University (Sechenov University)., Maev IV; Yevdokimov Moscow State University of Medicine and Dentistry., Sagalova OI; South Ural State Medical University., Sleptsova SS; Ammosov North-Eastern Federal University., Yushuk ND; Yevdokimov Moscow State University of Medicine and Dentistry., Gusev DA; Botkin Clinical Infectious Diseases Hospital., Zhdanov KV; Kirov Military Medical Academy., Chulanov VP; Sechenov First Moscow State Medical University (Sechenov University).; National Medical Research Center of Phthisiopulmonology and Infectious Diseases.
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2021 Nov 15; Vol. 93 (11), pp. 1290-1299. Date of Electronic Publication: 2021 Nov 15.
DOI:	10.26442/00403660.2021.11.201163
Abstrakt:	Aim: To study the efficacy and safety of bulevirtide, the HBV and HDV entry inhibitor. Materials and Methods: Analysis of the results of using bulevirtide in randomized controlled open-label comparative studies MYR202 and MYR203 in 56 patients with chronic hepatitis D and compensated cirrhosis, in monotherapy and combination with pegylated interferon alpha-2a (PEG-IFN). Results: Monotherapy with bulevirtide for 24 weeks in the MYR202 study in 46 patients with compensated liver cirrhosis demonstrated: 1) a high rate of virological (100%) and biochemical response (alanine aminotransferase normalization rate 45.7%), 2) superiority of bulevirtide in efficacy over the control group (tenofovir), 3) comparability of treatment efficacy in patients with and without cirrhosis, 4) no progression of liver fibrosis with elastometry in most patients. Treatment with bulevirtide in monotherapy and combination with PEG-IFN for 48 weeks in 10 patients with compensated liver cirrhosis in the MYR203 study was accompanied by a high rate of virological response (80%) and normalization of alanine aminotransferase (70%). Bulevirtide was well tolerated, there was no deterioration in tolerability compared with patients without cirrhosis, there were no serious adverse events and cases of treatment cancellation due to adverse events. Conclusion: Bulevirtide is recommended as the first line of treatment for chronic hepatitis D in patients with compensated cirrhosis in monotherapy and combination with PEG-IFN.
Databáze:	MEDLINE
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