Molecular Docking and Green Synthesis of Bioinorganic TiO 2 Nanoparticles against E.coli and S.aureus .

Autor: Al-Serwi RH; Department of Basic Dental Sciences, College of Dentistry, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., El-Sherbiny M; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia., Kumar TVA; Azidus Laboratories Ltd., Rathinamangalam, Chennai 600048, Tamil Nadu, India., Qasim AA; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia., Khattar T; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia., Alghazwani Y; Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Saudi Arabia., Alqahtani A; Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Saudi Arabia., Krishnaraju V; Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Saudi Arabia., Muthu Mohamed JM; Vaasudhara College of Pharmacy, Sante Circle, Chintamani Road, Hoskote 562114, Karnataka, India., Sundramurthy VP; Centre of Excellence for Bioprocess and Bio Technology, Department of Chemical Engineering, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia.
Jazyk: angličtina
Zdroj: Bioinorganic chemistry and applications [Bioinorg Chem Appl] 2022 Oct 15; Vol. 2022, pp. 1142727. Date of Electronic Publication: 2022 Oct 15 (Print Publication: 2022).
DOI: 10.1155/2022/1142727
Abstrakt: This study used a simple solution evaporation approach to make a bioinorganic titanium dioxide (Bi-TiO 2 ) photocatalyst for dye contaminant degradation. A variety of techniques, including X -ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) coupled with energy dispersive X -ray analysis (EDAX), and differential reflectance spectroscopy, had been employed to classify the structural and optical properties of the prepared bioinorganic photocatalyst (UV-DRS). Using simulated solar irradiation, the photocatalytic activity of the produced Bi-TiO 2 nanoparticles was examined by detecting the degradation of a solution of methylene blue (MB) as a model dye molecule. The developed Bi-TiO 2 photocatalyst demonstrates superior photocatalytic action than commercially available powder TiO 2 , according to photo-degradation experiments. E. coli and S. aureus bacterial strains were employed to assess the antibacterial activity of Bi-TiO 2 nanoparticles. The most active molecules that gain antibacterial activity were examined in isolated or extracted components from the tulsi plant. The chosen compounds were docked with thymidylate kinase (TMPK), a potential therapeutic goal for the preparation of novel antibacterial drugs with the PDB ID of 4QGG. Five compounds, namely rosmarinic acid, vicenin-2, orientin, vitexin, and isoorientin, out of the 27 chosen compounds, showed a higher docking score and may aid in boosting antibacterial activity. The synthesized Bi-TiO 2 nanoparticles produced antibacterial activity that was effective against Gram-positive bacteria. The nanomaterials that have been synthesized have a lot of potential in wastewater treatment and biomedical management technologies.
Competing Interests: The authors have no conflicts of interest.
(Copyright © 2022 Rasha Hamed Al-Serwi et al.)
Databáze: MEDLINE
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