E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice.

Autor:	Carll AP; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA. alex.carll@louisville.edu.; American Heart Association Tobacco Regulation and Addiction Center, Louisville, KY, USA. alex.carll@louisville.edu.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA. alex.carll@louisville.edu.; Department of Physiology, School of Medicine, University of Louisville, Louisville, KY, USA. alex.carll@louisville.edu.; Center for Integrative Environmental Health Sciences, School of Medicine, University of Louisville, Louisville, KY, USA. alex.carll@louisville.edu.; Division of Environmental Medicine, School of Medicine, University of Louisville, Louisville, KY, USA. alex.carll@louisville.edu., Arab C; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA.; Department of Cardiology, Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil., Salatini R; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA.; Department of Surgery, University of Sao Paulo Medical School, Sao Paulo, Brazil., Miles MD; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA., Nystoriak MA; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; American Heart Association Tobacco Regulation and Addiction Center, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA.; Division of Environmental Medicine, School of Medicine, University of Louisville, Louisville, KY, USA., Fulghum KL; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA.; Department of Physiology, School of Medicine, University of Louisville, Louisville, KY, USA.; Division of Environmental Medicine, School of Medicine, University of Louisville, Louisville, KY, USA., Riggs DW; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; American Heart Association Tobacco Regulation and Addiction Center, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA.; Division of Environmental Medicine, School of Medicine, University of Louisville, Louisville, KY, USA.; Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, USA., Shirk GA; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA.; Division of Environmental Medicine, School of Medicine, University of Louisville, Louisville, KY, USA., Theis WS; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; American Heart Association Tobacco Regulation and Addiction Center, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA.; Division of Environmental Medicine, School of Medicine, University of Louisville, Louisville, KY, USA., Talebi N; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA., Bhatnagar A; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; American Heart Association Tobacco Regulation and Addiction Center, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA.; Center for Integrative Environmental Health Sciences, School of Medicine, University of Louisville, Louisville, KY, USA.; Division of Environmental Medicine, School of Medicine, University of Louisville, Louisville, KY, USA., Conklin DJ; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, USA.; American Heart Association Tobacco Regulation and Addiction Center, Louisville, KY, USA.; Diabetes and Obesity Center, University of Louisville, Louisville, KY, USA.; Center for Integrative Environmental Health Sciences, School of Medicine, University of Louisville, Louisville, KY, USA.; Division of Environmental Medicine, School of Medicine, University of Louisville, Louisville, KY, USA.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2022 Oct 25; Vol. 13 (1), pp. 6088. Date of Electronic Publication: 2022 Oct 25.
DOI:	10.1038/s41467-022-33203-1
Abstrakt:	E-cigarette use has surged, but the long-term health effects remain unknown. E-cigarette aerosols containing nicotine and acrolein, a combustion and e-cigarette byproduct, may impair cardiac electrophysiology through autonomic imbalance. Here we show in mouse electrocardiograms that acute inhalation of e-cigarette aerosols disturbs cardiac conduction, in part through parasympathetic modulation. We demonstrate that, similar to acrolein or combustible cigarette smoke, aerosols from e-cigarette solvents (vegetable glycerin and propylene glycol) induce bradycardia, bradyarrhythmias, and elevations in heart rate variability during inhalation exposure, with inverse post-exposure effects. These effects are slighter with tobacco- or menthol-flavored aerosols containing nicotine, and in female mice. Yet, menthol-flavored and PG aerosols also increase ventricular arrhythmias and augment early ventricular repolarization (J amplitude), while menthol uniquely alters atrial and atrioventricular conduction. Exposure to e-cigarette aerosols from vegetable glycerin and its byproduct, acrolein, diminish heart rate and early repolarization. The pro-arrhythmic effects of solvent aerosols on ventricular repolarization and heart rate variability depend partly on parasympathetic modulation, whereas ventricular arrhythmias positively associate with early repolarization dependent on the presence of nicotine. Our study indicates that chemical constituents of e-cigarettes could contribute to cardiac risk by provoking pro-arrhythmic changes and stimulating autonomic reflexes. (© 2022. The Author(s).)
Databáze:	MEDLINE
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