| Autor: |
Guetchueng ST; Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé, Cameroon., Djouonzo PT; Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé, Cameroon., Lame Y; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon., Kopa Kowa T; Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé, Cameroon.; Natural Products Chemistry Research Unit, Department of Chemistry, Faculty of Sciences, University of Dschang, Dschang, Cameroon., Dotse E; Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Accra, Ghana., Tchokouaha LRY; Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé, Cameroon.; Department of Parasitology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Accra, Ghana., Kamdem Wabo H; Natural Products Chemistry Research Unit, Department of Chemistry, Faculty of Sciences, University of Dschang, Dschang, Cameroon., Appiah-Opong R; Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Accra, Ghana., Agbor GA; Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé, Cameroon. |
| Abstrakt: |
Phytochemical investigation of the rhyzomes of Rumex abyssinicus (Polygonaceae) afforded six anthraquinones viz chrysophanol ( 1 ), physcion ( 2 ), emodin ( 3 ), mixture of physcion-8- O - β ,D-glucopyranoside ( 4 ) and chrypsophanol-8- O - β ,D-glucopyranoside ( 5 ), and emodin-8- O - β ,D-glucopyranoside ( 6 ). All the compounds were characterised and identified by comparison of their MS and NMR data with available literature data. The isolated compounds were evaluated for their antileishmanial activity. Emodin ( 3 ) was the most active compounds with IC 50 13.82 and 0.26 µg/mL against Leishmania donovani amastigotes and promastigotes, respectively. Emodin-8- O - β ,D-glucopyranoside ( 6 ) also showed a moderate activity with IC 50 27.53 and 37.08 µg/mL. This is the first report of antileishmanial compounds from R. abyssinicus and the antileishmanial activities of compounds 2 , 4 , 5 and 6 are here reported for the first time. |
