Safety and Immunogenicity of Intradermal Fractional Dose Administration of the mRNA-1273 Vaccine: A Proof-of-Concept Study.

Autor: Roozen GVT; Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands., Prins MLM; Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands., van Binnendijk R; Department of Immune Surveillance, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., den Hartog G; Department of Immune Surveillance, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Kuiper VP; Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands., Prins C; Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands., Janse JJ; Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands., Kruithof AC; Department of Infectious Diseases, Leiden University Medical Center, and Centre for Human Drug Research, Leiden, the Netherlands., Feltkamp MCW; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Kuijer M; Department of Immune Surveillance, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Roestenberg M; Department of Infectious Diseases and Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands., Visser LG; Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands., Roukens AHE; Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Jazyk: angličtina
Zdroj: Annals of internal medicine [Ann Intern Med] 2022 Dec; Vol. 175 (12), pp. 1771-1774. Date of Electronic Publication: 2022 Oct 25.
DOI: 10.7326/M22-2089
Databáze: MEDLINE