[The use of drinking mineral water and low-intensity electromagnetic radiation at an early stage of metabolic syndrome development (experimental study)].

Autor:	Korolev YN; National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia., Nikulina LA; National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia., Mikhailik LV; National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury [Vopr Kurortol Fizioter Lech Fiz Kult] 2022; Vol. 99 (5), pp. 54-59.
DOI:	10.17116/kurort20229905154
Abstrakt:	Purpose of the Study: To reveal the features of adaptive metabolic development, light-optical and ultrastructural reactions under the combined action of drinking mineral water (MW) and low-intensity electromagnetic radiation (EMR) of ultrahigh frequency (UHF) at an early stage of development of the experimental metabolic syndrome. Material and Methods: The study was performed on 28 non-linear male rats weighing 180-200 g. Animals of the experimental group on the background of a high-calorie diet received at first (from the 8th day of the experiment) a course of drinking sulfate MW (24 procedures), and after its completion - a course of low-intensity EMR UHF (12 procedures), daily, 2 minutes per lumbar region in the zone projections of the adrenal glands using the Aquaton-2 device (power flux density 1 μW/cm 2 , frequency 1000 MHz). Animals fed only a high-calorie diet served as controls; intact animals were also used. The objects of study were the liver, blood, thymus. Biochemical, histological, electron microscopic and morphometric research methods were used. Results and Discussion: The combined use of drinking MW and low-intensity UHF EMR contributed to the development of adaptive metabolic and regenerative processes: the level of glucose and high-density lipoproteins decreased in the blood, antioxidant activity clearly increased in the liver, the content of RNA, DNA and total protein increased, and the number of dystrophic and necrobiotic cells decreased. Strengthening of the processes of intracellular regeneration was manifested in an increase in the number of mitochondria, peroxisomes, as well as protein-synthesizing organelles - ribosomes and polysomes. Functional activity of the lysosomal system increased. The number of nuclei increased In thymus and specific activity of the thymocyte genome increased as well. The revealed effects were mainly due to the antioxidant, membrane stabilizing, detoxifying, and immunomodulatory effects of MW and UHF EMR. Conclusion: Based on the data obtained, it can be concluded that the combined use of drinking MW and low-intensity UHF EMR can be very promising in the light of the development of new approaches to the treatment and prevention of metabolic syndrome in the early stages of its development. To optimize the adaptive-protective and compensatory processes, more adequate modes of combined exposure to MW and UHF EMR should be used.
Databáze:	MEDLINE
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