Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age.

Autor:	Edmondson-Stait AJ; Translational Neuroscience PhD Programme, Centre for Clinical Brain Sciences, University of Edinburgh, UK., Shen X; Centre for Clinical Brain Sciences, University of Edinburgh, UK., Adams MJ; Centre for Clinical Brain Sciences, University of Edinburgh, UK., Barbu MC; Centre for Clinical Brain Sciences, University of Edinburgh, UK., Jones HJ; National Institute for Health Research Bristol Biomedical Research Centre, At University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, UK.; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK.; Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, UK., Miron VE; Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, UK., Allardyce J; Centre for Clinical Brain Sciences, University of Edinburgh, UK., Boardman JP; Centre for Clinical Brain Sciences, University of Edinburgh, UK.; Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, UK., Lawrie SM; Centre for Clinical Brain Sciences, University of Edinburgh, UK., McIntosh AM; Centre for Clinical Brain Sciences, University of Edinburgh, UK., Khandaker GM; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK.; Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, UK., Kwong ASF; Centre for Clinical Brain Sciences, University of Edinburgh, UK., Whalley HC; Centre for Clinical Brain Sciences, University of Edinburgh, UK.
Jazyk:	angličtina
Zdroj:	Brain, behavior, & immunity - health [Brain Behav Immun Health] 2022 Oct 10; Vol. 26, pp. 100528. Date of Electronic Publication: 2022 Oct 10 (Print Publication: 2022).
DOI:	10.1016/j.bbih.2022.100528
Abstrakt:	Inflammation is implicated in depression and psychosis, including association of childhood inflammatory markers on the subsequent risk of developing symptoms. However, it is unknown whether early-life inflammatory markers are associated with the number of depressive and psychotic symptoms from childhood to adulthood. Using the prospective Avon Longitudinal Study of Children and Parents birth cohort (N = up-to 6401), we have examined longitudinal associations of early-life inflammation [exposures: interleukin-6 (IL-6), C-reactive protein (CRP) levels at age 9y; IL-6 and CRP DNA-methylation (DNAm) scores at birth and age 7y; and IL-6 and CRP polygenic risk scores (PRSs)] with the number of depressive episodes and psychotic experiences (PEs) between ages 10-28 years. Psychiatric outcomes were assessed using the Short Mood and Feelings Questionnaire and Psychotic Like Symptoms Questionnaires, respectively. Exposure-outcome associations were tested using negative binomial models, which were adjusted for metabolic and sociodemographic factors. Serum IL-6 levels at age 9y were associated with the total number of depressive episodes between 10 and 28y in the base model (n = 4835; β = 0.066; 95%CI:0.020-0.113; pFDR = 0.041) which was weaker when adjusting for metabolic and sociodemographic factors. Weak associations were observed between inflammatory markers (serum IL-6 and CRP DNAm scores) and total number of PEs. Other inflammatory markers were not associated with depression or PEs. Early-life inflammatory markers are associated with the burden of depressive episodes and of PEs subsequently from childhood to adulthood. These findings support a potential role of early-life inflammation in the aetiology of depression and psychosis and highlight inflammation as a potential target for treatment and prevention. Competing Interests: All authors have nothing to disclose. (© 2022 The Author(s).)
Databáze:	MEDLINE
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