Biomarkers predicting the 30‑day mortality of patients who underwent elective surgery and were infected with SARS‑CoV‑2 during the post‑operative period: A retrospective study.

Autor: Georgakopoulou VE; Department of Infectious Diseases-COVID-19 Unit, Laiko General Hospital, 11527 Athens, Greece., Basoulis D; Department of Infectious Diseases-COVID-19 Unit, Laiko General Hospital, 11527 Athens, Greece.; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece., Voutsinas PM; Department of Infectious Diseases-COVID-19 Unit, Laiko General Hospital, 11527 Athens, Greece., Papageorgiou CV; Pulmonology Department, Laiko General Hospital, 11527 Athens, Greece., Eliadi I; Department of Infectious Diseases-COVID-19 Unit, Laiko General Hospital, 11527 Athens, Greece., Karamanakos G; Department of Infectious Diseases-COVID-19 Unit, Laiko General Hospital, 11527 Athens, Greece., Spandidos DA; Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece., Mathioudakis N; Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece., Papalexis P; Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.; Department of Biomedical Sciences, University of West Attica, 12243 Athens, Greece., Papadakos S; Department of Gastroenterology, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece., Fotakopoulos G; Department of Neurosurgery, General University Hospital of Larisa, 41221 Larisa, Greece., Tarantinos K; 1st Pulmonology Department, Sismanogleio Hospital, 15126 Athens, Greece., Sipsas NV; Department of Infectious Diseases-COVID-19 Unit, Laiko General Hospital, 11527 Athens, Greece.; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2022 Sep 27; Vol. 24 (5), pp. 693. Date of Electronic Publication: 2022 Sep 27 (Print Publication: 2022).
DOI: 10.3892/etm.2022.11629
Abstrakt: The coronavirus disease 2019 (COVID-19) pandemic is a significant global concern that has had major implications for the healthcare system. Patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) undergoing elective or emergency surgical procedures have a substantial risk of mortality and peri-operative complications. The present study aimed to describe the characteristics of patients who underwent elective surgery and developed nosocomial SARS-CoV-2 infection post-surgery. Patients who underwent thoracic, upper and lower abdominal or peripheral elective surgery with a polymerase chain reaction diagnosis of COVID-19, at 3-7 days after the surgery, were enrolled in the present retrospective study. Demographics, vaccination status against SARS-CoV-2, Charlson comorbidity index (CCI) and laboratory data were recorded upon admission to the hospital unit. In total, 116 subjects (80 males, 36 females; mean age, 67.31±16.83 years) fulfilling the inclusion criteria were identified. Among the 116 participants, 14 (12.1%) were intubated. From the 116 individuals analyzed, 84 were alive after 30 days (survivors), and 32 had succumbed to the disease (non-survivors). The mortality rate was 27.6% (32/116). The non-survivors had an older age and a higher CCI score. At the evaluation upon admission to the hospital unit, the survivors presented with higher serum albumin levels and a higher number of blood lymphocytes. In addition, the survivors exhibited lower levels of lactate dehydrogenase, aspartate aminotransferase, alkaline phosphatase (ALP) and C-reactive protein (CRP), as well as a higher neutrophil to lymphocyte ratio (NLR) and CRP to albumin ratio (CAR) (P<0.05). The patients that were intubated had higher levels of gamma glutamyl-transferase (GGT), ALP and ferritin, as well as a higher NLR and platelet to lymphocyte ratio upon admission to the hospital unit (P<0.05). According to the Cox proportional hazards multivariate regression analysis, the only independent predictors of mortality and intubation were ALP and GGT upon admission, respectively (P<0.05). On the whole, the findings of the present study suggest that more stringent guidelines are required in order to prevent infection during the post-operative period.
Competing Interests: DAS is the Editor-in-Chief for the journal, but had no personal involvement in the reviewing process, or any influence in terms of adjudicating on the final decision, for this article. The other authors declare that they have no competing interests.
(Copyright: © Georgakopoulou et al.)
Databáze: MEDLINE
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