Human pandemic K27-ST392 CTX-M-15 extended-spectrum β-lactamase-positive Klebsiella pneumoniae : A one health clone threatening companion animals.

Autor: da Silva LCBA; Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.; School of Veterinary Medicine, Metropolitan University of Santos, Santos, Brazil., Cardoso B; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil.; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Fontana H; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil.; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Esposito F; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil.; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Cortopassi SRG; Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil., Sellera FP; School of Veterinary Medicine, Metropolitan University of Santos, Santos, Brazil.; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil.; Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil., Lincopan N; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil.; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: One health (Amsterdam, Netherlands) [One Health] 2022 Jul 03; Vol. 15, pp. 100414. Date of Electronic Publication: 2022 Jul 03 (Print Publication: 2022).
DOI: 10.1016/j.onehlt.2022.100414
Abstrakt: Extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae is a medically important pathogen that commonly causes human nosocomial infections. Since veterinary emergency and critical care services have also significantly progressed over the last decades, there are increasing reports of ESBL-producing K. pneumoniae causing hospital-associated infections in companion animals. We present microbiological and genomic analysis of a multidrug-resistant ESBL-positive K. pneumoniae (LCKp01) isolated from a fatal infection in a dog admitted to a veterinary intensive care unit. LCKp01 strain belonged to the sequence type ST392 and displays a KL27 (wzi-187) and O-locus 4 (O4). A broad resistome and presence of the bla CTX-M-15 ESBL gene were predicted. SNP-based phylogenomic analysis, using an international genome database, clustered LCKp01 (60-80 SNPs differences) with K. pneumoniae ST392 from human and animal infections, isolated at 4-year interval, whereas phylogeographical analysis confirmed successful expansion of ST392 as a global clone of One Health concern.
Competing Interests: All authors declare no conflicts of interest.
(© 2022 The Authors.)
Databáze: MEDLINE
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