Intramuscular injection of a mixture of COVID-19 peptide vaccine and tetanus vaccine in horse induced neutralizing antibodies against authentic virus of SARS-CoV-2 Delta variant.
| Autor: | Deng W; Behring Therapeutics, Inc., 50 Bridge Street, Shelton, CT, USA., Sweeney RW; Department of Clinical Studies-New Bolton Center, University of Pennsylvania School of Veterinary Medicine, 382, West Street Road, Kennett Square, PA, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Vaccine: X [Vaccine X] 2022 Dec; Vol. 12, pp. 100230. Date of Electronic Publication: 2022 Oct 19. |
| DOI: | 10.1016/j.jvacx.2022.100230 |
| Abstrakt: | Peptide vaccine is not effective due to its low immunogenicity. To improve the efficacy of peptide vaccine against COVID-19, a novel method was developed by mixing a COVID-19 peptide vaccine with a tetanus vaccine. In this study, intramuscular injection of a mixture of COVID-19 peptide vaccine and tetanus vaccine twice, i.e., first dose on day 0 and second dose on day 21, induced neutralizing antibodies against authentic virus of SARS-CoV-2 Delta variant in a horse. Horse serum of day 35, i.e., two weeks after the second dose, neutralized authentic virus of SARS-CoV-2 Delta variant, equal to half effectiveness of human serum from vaccinees of Moderna COVID-19 vaccine. However, neither horse serum nor human serum neutralized Omicron variant authentic virus. No side effects were observed after each dose. This study indicates intramuscular injection of a mixture of COVID-19 peptide vaccine and tetanus vaccine may work in humans to improve peptide vaccine efficacy against SARS-CoV-2. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Weiwen Deng has a relationship with Behring Therapetuics, Inc. that includes board membership. Weiwen Deng is inventor on a U.S. provisional patent application (63/345,049) related to the methodology described in the present study. The remaining author declares no competing interests. (© 2022 The Author(s).) |
| Databáze: | MEDLINE |
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