Irradiation of UVC LED at 277 nm inactivates coronaviruses in association to photodegradation of spike protein.

Autor:	Ong Q; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, Singapore., Ronnie Teo JW; Singapore Institute of Manufacturing Technology (SIMTech), Agency for Science, Technology and Research (A∗STAR), 2 Fusionopolis Way, #08-04, Innovis, 138634, Singapore., Dela Cruz J; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, Singapore., Wee E; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, Singapore., Wee W; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, Singapore., Han W; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, #02-02, Helios, 138667, Singapore.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2022 Oct; Vol. 8 (10), pp. e11132. Date of Electronic Publication: 2022 Oct 17.
DOI:	10.1016/j.heliyon.2022.e11132
Abstrakt:	To interrupt SARS-CoV-2 transmission chains, Ultraviolet-C (UVC) irradiation has emerged as a potential disinfection tool to aid in blocking the spread of coronaviruses. While conventional 254-nm UVC mercury lamps have been used for disinfection purposes, other UVC wavelengths have emerged as attractive alternatives but a direct comparison of these tools is lacking with the inherent mechanistic properties unclear. Our results using human coronaviruses, hCoV-229E and hCoV-OC43, have indicated that 277-nm UVC LED is most effective in viral inactivation, followed by 222-nm far UVC and 254-nm UVC mercury lamp. While UVC mercury lamp is more effective in degrading viral genomic content compared to 277-nm UVC LED, the latter results in a pronounced photo-degradation of spike proteins which potentially contributed to the higher efficacy of coronavirus inactivation. Hence, inactivation of coronaviruses by 277-nm UVC LED irradiation constitutes a more promising method for disinfection. Competing Interests: The authors declare no conflict of interest. (© 2022 The Author(s).)
Databáze:	MEDLINE
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